艾滋病合并侵袭性真菌病相关免疫重建炎症综合征
Invasive fungal diseases-related immune reconstitution inflammatory syndrome in AIDS patients
张沁枝 1郭朋乐 1李凌华1
作者信息
- 1. 广州医科大学附属市八医院感染病中心,广州 510440
- 折叠
摘要
侵袭性真菌病(invasive fungal disease,IFD)是AIDS患者常见的机会性感染,部分患者启动抗逆转录病毒治疗后出现IFD相关免疫重建炎症综合征(immune reconstitution inflammatory syndrome,IRIS),引起强烈炎症反应,使患者病情再度恶化.IFD相关IRIS临床特征不典型,常导致诊断及治疗延迟,但其发生机制尚不明确.本文拟对AIDS合并IFD相关IRIS流行情况、发生机制、危险因素、临床特征及诊疗方案相关研究进展进行综述,以提高对该病的认识和诊治水平.
Abstract
Invasive fungal disease(IFD)is a common opportunistic infection among AIDS patients,with some patients developing IFD-related immune reconstitution inflammatory syndrome(IRIS)following the initiation of antiretroviral therapy(ART).IFD-related IRIS triggers a robust inflammatory response,leading to a deterioration of the patient's condition.The clinical manifestations of IFD-related IRIS are often ambiguous,resulting in delayed diagnosis and treatment,yet its underlying mechanisms remain unclear.In this article,the prevalence,pathogenesis,risk factors,clinical features,and therapeutic strategies of IFD-related IRIS in AIDS patients are summarized,aiming to improve the knowledge and optimize the diagnosis and treatment strategies.
关键词
获得性免疫缺陷综合征/免疫重建炎症综合征/侵袭性真菌病/糖皮质激素Key words
Acquired immune deficiency syndrome/Immune reconstitution inflammatory syndrome/Invasive fungal diseases/Glucocorticoid引用本文复制引用
基金项目
广东省医学基金项目(A2023333)
广州市科技计划(2023A03J0793)
广州市科技计划(2023A03J0794)
广州市科技计划(202201020276)
2021-2023年广州市医学重点学科()
出版年
2024
NETL
NSTL
万方数据