首页|艾滋病合并侵袭性真菌病相关免疫重建炎症综合征

艾滋病合并侵袭性真菌病相关免疫重建炎症综合征

Invasive fungal diseases-related immune reconstitution inflammatory syndrome in AIDS patients

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侵袭性真菌病(invasive fungal disease,IFD)是AIDS患者常见的机会性感染,部分患者启动抗逆转录病毒治疗后出现IFD相关免疫重建炎症综合征(immune reconstitution inflammatory syndrome,IRIS),引起强烈炎症反应,使患者病情再度恶化.IFD相关IRIS临床特征不典型,常导致诊断及治疗延迟,但其发生机制尚不明确.本文拟对AIDS合并IFD相关IRIS流行情况、发生机制、危险因素、临床特征及诊疗方案相关研究进展进行综述,以提高对该病的认识和诊治水平.
Invasive fungal disease(IFD)is a common opportunistic infection among AIDS patients,with some patients developing IFD-related immune reconstitution inflammatory syndrome(IRIS)following the initiation of antiretroviral therapy(ART).IFD-related IRIS triggers a robust inflammatory response,leading to a deterioration of the patient's condition.The clinical manifestations of IFD-related IRIS are often ambiguous,resulting in delayed diagnosis and treatment,yet its underlying mechanisms remain unclear.In this article,the prevalence,pathogenesis,risk factors,clinical features,and therapeutic strategies of IFD-related IRIS in AIDS patients are summarized,aiming to improve the knowledge and optimize the diagnosis and treatment strategies.

Acquired immune deficiency syndromeImmune reconstitution inflammatory syndromeInvasive fungal diseasesGlucocorticoid

张沁枝、郭朋乐、李凌华

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广州医科大学附属市八医院感染病中心,广州 510440

获得性免疫缺陷综合征 免疫重建炎症综合征 侵袭性真菌病 糖皮质激素

广东省医学基金项目广州市科技计划广州市科技计划广州市科技计划2021-2023年广州市医学重点学科

A20233332023A03J07932023A03J0794202201020276

2024

10.3760/cma.j.cn331340-20240102-00002

国际流行病学传染病学杂志
中华医学会,浙江省医学科学院

国际流行病学传染病学杂志

CSTPCD
影响因子：0.424
ISSN：1673-4149
年,卷(期)：2024.51(2)
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