艾滋病患者结核病相关免疫重建炎症综合征免疫机制研究进展
Advances in the immune mechanisms of tuberculosis related immune reconstitution inflammatory syndrome in AIDS patients
杨隆平 1陈景良 1李凌华1
作者信息
- 1. 广州医科大学附属市八医院感染病中心,广州 510440
- 折叠
摘要
结核病是艾滋病最常见机会性感染之一.启动抗逆转录病毒治疗后,艾滋病合并结核病患者可能出现结核病相关免疫重建炎症综合征(TB-IRIS),使病情恶化,导致再次住院甚至死亡.目前针对TB-IRIS发病机制已经有大量研究,但其潜在免疫机制及相关预测因子仍不明确.本文拟对艾滋病患者TB-IRIS的流行现状、高危因素、预测因子及免疫机制的研究进展进行综述,以提高对该疾病的认识.
Abstract
Tuberculosis is one of the most common opportunistic infections in AIDS patients.Following the initiation of antiretroviral therapy(ART),HIV and Mycobacterium tuberculosis co-infected patients may experience tuberculosis-associated immune reconstitution inflammatory syndrome(TB-IRIS),leading to disease exacerbation,recurrent hospitalizations,and even death.Although extensive research has been conducted on the pathogenesis of TB-IRIS,the underlying immunological mechanisms and associated predictive factors remain unclear.This review aims to summarize the current epidemiology,high-risk factors,predictive factors,and immunological mechanisms of TB-IRIS,in order to enhance the understanding.
关键词
免疫重建炎症综合征/结核病/获得性免疫缺陷综合征/合并感染Key words
Immune reconstitution inflammatory syndrome/Tuberculosis/Acquired immune deficiency syndrome/Co-infection引用本文复制引用
出版年
2024
NETL
NSTL
万方数据