宏基因组测序技术在脓肿疾病诊断中的应用研究
Application of metagenomics next-generation sequencing in diagnosis of abscess disease
张昊悦 1汤正好1
作者信息
- 1. 上海交通大学医学院附属第六人民医院感染病科,上海 200233
- 折叠
摘要
随着脓肿疾病越来越高发,传统的微生物培养方法因其培养周期长、阳性率低等缺点,已不能满足临床需求.基于测序技术的快速发展,宏基因组学技术已广泛运用于临床,不仅能快速准确地鉴定微生物种群结构和多样性,还能鉴定多种致病菌及基因功能,成为病原学诊断的新选择.本文就近年来宏基因组学技术在脓肿病原学诊断中的应用和发展作一综述.
Abstract
With the increasing prevalence of abscess diseases,traditional microbiological culture methods have become inadequate for clinical needs due to their long incubation periods and low positive rates.Based on the rapid development of sequencing technology,metagenomics technology has been extensively used in clinical practice,enabling the rapid and accurate identification of microbial community structures and diversity,as well as the detection of various pathogenic bacteria and gene functions.Metagenomics has emerged as a new option for pathogenic diagnosis.In this paper,the application and development of metagenomics technology in the pathogenic diagnosis of abscesses are reviewed.
关键词
宏基因组学/脓肿/二代测序/微生物Key words
Metagenomics/Abscess/Next generation sequencing/Microorganism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据