Effect of mitomycin bladder perfusion thermochemotherapy combined with Recoen holmium la-ser resection on the expression of serum Dickkopf-1 and α-FR in patients with non-invasive bladder cancer
Objective The effect of mitomycin bladder perfusion thermochemotherapy com-bined with Recoen holmium laser electrotomy on the expression of serum Dickkopf-1 and alpha-folate receptor(α-FR)in patients with non-invasive bladder cancer.Methods From May 2017 to Jan 2020,136 patients with non-invasive bladder cancer who were treated in our hospital and all patients were divided into control group and observation group by random number table method,with 68 people in each group.The control group was treated with Recoen holmium laser resection,and the observation group was given mitomycin bladder perfusion thermochemotherapy combined with Recoen holmium laser resection.The clinical efficacy,immune function-related indexes,serum Dickkopf-1 and α-FR levels,adverse reactions and recurrences,and long-term survival 2 months before and after treatment.Results After 2 months of treatment,the control rate of the control group was 55.88％(38/68),and the re-mission rate was 79.41％(54/68),the control rate of the observation group was 79.41％(54/68),and the remission rate was 94.12％(64/68).The differences in control rate and remission rate be-tween the two groups were statistically significant(all P＜0.05).After 2 months of treatment,the hu-moral immune cell indicators(immunoglobulin A,immunoglobulin G and immunoglobulin M),CD4+and CD4+/CD8+levels of the observation group were significantly higher than those of the control group,and the CD8+level of the observation group was significantly lower Control group(all P＜0.05).After treatment,the serum Dickkopf-1 and α-FR levels of the two groups were significantly re-duced,and the serum Dickkopf-1 and α-FR levels of the observation group were significantly lower than those of the control group(all P＜0.05).In addition,the differences in serum Dickkopf-1 andα-FR levels between the two groups before and after treatment were statistically significant(all P＜0.05).Within 2 months of treatment,the total adverse reaction rate in the control group was 22.06％(15/68),and the total adverse reaction rate in the observation group was 19.12％(13/68),and the difference in the total adverse reaction rate between the two groups was not statistically significant(P＞0.05).The recurrence rate of the observation group within 2 years after treatment was significantly lower than that of the control group(P＜0.05).Conclusions Mitomycin bladder perfusion thermo-chemotherapy combined with Recoen holmium laser resection is effective in treating non-invasive blad-der cancer.It can enhance anti-tumor effect,effectively improve clinical efficacy,improve body fluid immunity and cellular immune function,and reduce serum Dickkopf-1 and α-FR levels,improve dis-ease control rate and remission rate,and did not increase adverse reactions.
Urinary Bladder NeoplasmsMitomycinIrrigation of BladderCystectomyDick-kopf-1α-FR
NETL
NSTL
万方数据
维普
