The value of SⅡ index changes before and after neoadjuvant chemotherapy in evaluating the prognosis of locally advanced prostate cancer
Objective To explore the prognostic value of changes in systemic immune inflam-mation index(SⅡ)before and after neoadjuvant chemotherapy for locally advanced prostate cancer.Methods The clinical data of 100 patients with locally advanced prostate cancer who received neoad-juvant chemotherapy and radical prostatectomy in our hospital from July 2019 to June 2021 were col-lected.SⅡ was calculated according to the blood routine results 1 day before neoadjuvant chemotherapy and 21 days after neoadjuvant chemotherapy,and then the patients were divided into an increased SⅡgroup(40 cases)and a decreased SⅡ group(60 cases)according to the changes of SⅡ.The relation-ship between the changes of SⅡ and the clinical characteristics and prognosis of patients with locally advanced prostate cancer were analyzed.The related factors affecting the prognosis of patients with lo-cally advanced prostate cancer were explored by multivariate Cox analysis.Results The proportions of prostate specific antigen(PSA)≥20 μg/L,lymph node metastasis,postoperative complications and postoperative adjuvant chemotherapy in the SⅡ-increased group were higher when compared with the SⅡ-decreased group(all P＜0.05).The postoperative clinical remission rate(62.50％)in the SⅡ-increased group was lower when compared with the SⅡ-decreased group(83.33％)(P＜0.05).All patients in this study were followed up for 12 months,and the overall survival rate was 78.00％,of which the 1-year survival rate of the SⅡ-increased group(65.00％)was lower when compared with the SⅡ-decreased group(86.67％)(P＜0.05).PSA,lymph node metastasis,postoperative complica-tions,postoperative adjuvant chemotherapy and changes in SⅡ were associated with the 1-year survival rate of patients with locally advanced prostate cancer(all P＜0.05).PSA ≥20 μg/L,lymph node metastasis,postoperative complications,absence of postoperative adjuvant chemotherapy,and elevated SⅡ were all risk factors affecting the prognosis of patients with locally advanced prostate cancer(all P＜0.05).Conclusions The change of SⅡ index before and after neoadjuvant chemotherapy can be used as an effective indicator to evaluate the prognosis of locally advanced prostate cancer,and the increase of SⅡ index indicates a poor prognosis of locally advanced prostate cancer.
Prostatic NeoplasmsChemotherapyImmune-Inflammation Index
NETL
NSTL
万方数据
