ROC curve analysis of the significance of blood IL-6,CRP and TNF-α expression in patients after ureteral calculi and the predictive value of infection complications
Objective To investigate the expression of interleukin-6(IL-6),C-reactive pro-tein(CRP),tumor necrosis factor-α(TNF-α)in patients after ureteral calculi and their predictive value for infection complications.Methods From February 2021 to May 2022,61 patients with infec-tion after ureteral calculi in our hospital were selected as the study group and 61 patients without infec-tion were set as the control group.The levels of IL-6,CRP and TNF-α were compared between the two groups of patients with different infection conditions,and the correlation between serum indexes and postoperative infection and disease conditions and the predictive value of postoperative infection were analyzed.Results Immediately after surgery,6 hours after surgery,and 24 hours after surgery,the levels of serum IL-6,CRP,and TNF-α in the control group showed a decreasing trend,and the study group showed a single-peak trend,the serum levels of IL-6,CRP and TNF-α in the study group were higher than those in the control group(all P＜0.05).The levels of serum IL-6,CRP and TNF-α at different time periods after operation were significantly associated with postoperative infection of ureteral calculi(all P＜0.05).The sensitivity of the cutoff values of IL-6 and TNF-α at 6 hours after surgery was relatively high(85.25％vs.68.85％).Serum IL-6,CRP and TNF-α levels were selected as joint prediction at 6 hours after operation.ROC curve analysis showed that AUC was 0.901,sensitivity was 85.25％,and specificity was 85.25％,and the levels of IL-6,CRP,and TNF-α were higher in patients with systemic infection at 6 hours after surgery than those with local infection(P＜0.05).The levels of IL-6,CRP and TNF-α in patients with different degrees of infection were significantly differ-ent,and their levels continued to increase with the increase of the degree of disease(all P＜0.05).There was a positive correlation between the levels of serum IL-6,CRP,and TNF-α at 6 hours after surgery and the infection and the degree of illness(all P＜0.05).Conclusions The changes of IL-6,CRP and TNF-α in blood can be used as a predictor of infection after ureteral calculi,and can help to assess the severity of infection.Detecting the above factors can help improve the treatment plan.
NETL
NSTL
万方数据
维普
