Microbiological analysis of urinary tract infection in children with urinary calculi
Objective To analyze the results of pathogenic microorganism and drug sensitivity test in children with urinary calculi complicated with infection,and to explore the correlation between the incidence of urinary calculi and urinary tract infection in children.Methods Urine samples were collected from 100 normal children(under 14 years old)hospitalized in the Child Care Clinic of Peo-ple's Hospital of Xinjiang Uygur Autonomous Region from October 2018 to November 2019 as the con-trol group,and urine samples from 100 children hospitalized in the Urological Center of People's Hos-pital of Xinjiang Uygur Autonomous Region as the case group.Urine routine examination and drug re-sistance detection were performed to analyze the distribution of fine bacteria in the urine of the chil-dren.Results The proportion of male in the case group was higher than that in the control group,and the positive rates of urine routine,urine bacterial culture,blood routine serum white blood cell,CRP and other indicators in the case group were higher than those in the control group,with statistically sig-nificant differences between the two groups(all P＜0.05).Logistic regression analysis of infection in-dicators showed that urinary routine,bacterial culture,serum white blood cell,CRP and other infec-tion indicators were related to urinary calculi(all P＜0.05),and positive infection indicators were risk factors for urinary calculi(OR＞1).The predictive model was established by logistic regression,and the results showed that gender,serum leukocyte positive,CRP positive,and urine routine positive were effective predictors of urinary calculi.The area under the ROC curve of the predictive model was 0.879(95％CI:0.829-0.928),the cut off value was 26.61％.In the case group,61 cases of urina-ry tract infection,a total of 20 strains were detected,of which 7 strains(35％)were gram-positive and 13 strains(65％)were gram-negative.The resistance to tetracycline,levofloxacin and other antibiot-ics was low in gram-positive ingot.The resistance to imipenem,piperacillin/tazobactam,meropenem,ceftazidime and other antibiotics was low.Conclusions Urinary tract infection rate in children with u-rinary calculus is higher than that in normal children.Escherichia coli infection is the main pathogenic microorganism leading to urinary tract infection in children with urinary calculi in our hospital.Gram-positive strains had low resistance to tetracycline,levofloxacin and other antibiotics.Gram-negative bacteria had low resistance to antibiotics such as imipenem,piperacillin/tazobactam,meropenem and ceftazidime.In order to obtain better curative effect.
NETL
NSTL
万方数据
维普
