Study on expression of serum FIB,IL-6 and their correlation with urodynamic parameters in patients with benign prostatic hyperplasia
Objective To observe the expression of serum fibrinogen(FIB)and interleukin-6(IL-6)in patients with benign prostatic hyperplasia(BPH),and to analyze the relationship between them and urodynamic parameters.Methods From August 2019 to August 2021,120 patients with BPH treated in the hospital were selected as the observation group,another 60 patients with chronic prostatitis(CP)were selected as the control group,according to the Schafer classification recommen-ded by International Continence Society(ICS),the patients were divided into no obstruction group(25 cases),suspected obstruction group(32 cases)and obstruction group(63 cases).The baseline data questionnaire of patients were designed,the baseline data and laboratory indexes of patients in the ob-servation group and the control group and patients with different degrees of obstruction were compared.The expression of serum FIB and IL-6 in patients with BPH and their relationship with urodynamic pa-rameters were mainly analyzed.Results The proportion of acute urinary retention,maximum detrusor muscle pressure(Pdetmax),residual urine volume(PVR),FIB and IL-6 in observation group were higher than those in control group,and the maximum urinary flow rate(Qmax)in observation group was lower than that in control group,with statistical significance(all P＜0.001).The proportion of acute urinary retention in obstruction group was the highest,followed by suspected obstruction group,and the lowest in non-obstruction group,with statistical significance(all P＜0.05).Pdetmax,PVR,serum FIB,IL-6 were the highest in obstruction group,followed by suspected obstruction group,and the low-est in non-obstruction group,with statistical significance(all P＜0.001).Qmax was the lowest in the obstruction group,followed by the suspected obstruction group,and the highest in the non-obstruction group,with statistical significance(all P＜0.001).By the Pearson bivariate correlation test,the re-sults showed that the serum FIB,IL-6 express respectively with BPH patients Pdet max,PVR were posi-tively correlated(r＞0,P＜0.05),patients with BPH Q max negatively correlated(r＜0,P＜0.05).The decision curve was drawn with the net rate of return as the vertical coordinate and the high risk threshold as the horizontal coordinate.The results showed that the net rate of return in the combined assessment of serum FIB and IL-6 for suspected obstruction of bladder outlet in BPH patients was better than the net rate of return of the two alone.Moreover,in the range of high risk threshold 0-1.0,the net return rate of suspected bladder outlet obstruction and obstruction in BPH patients as-sessed by serum FIB and IL-6 alone and in combination was always＞0,which has clinical signifi-cance.The results of orderly regression analysis showed that high levels of serum FIB and IL-6 were risk factors for bladder outlet obstruction in BPH patients(OR＞1,all P＜0.05).Conclusions Aerum FIB and IL-6 are abnormally expressed in patients with BPH,and they are related to urodynam-ic parameters.
NETL
NSTL
万方数据
维普
