Application of high-throughput hemodialysis in the treatment of secondary hyperparathyroid-ism in uremic patients
Objective To analyze the effect of high-flux hemodialysis in uremic patients with secondary hyperparathyroidism(SHPT).Methods From June 2018 to June 2020,64 uremic patients with secondary SHPT who underwent hemodialysis in our hospital were selected and randomly divided into experimental group and control group,with 32 cases in each group.The experimental group re-ceived high-flux hemodialysis and the control group received low-flux hemodialysis.The serum calci-um,phosphorus,parathyroid hormone(iPTH),bone alkaline phosphatase before treatment and 3,6,9,12 months after treatment were compared between the two groups.And alkaline phosphatase levels,and the survival rates of the two groups were compared.Results The levels of blood phosphorus,iPTH and bone alkaline phosphatase in each time period after dialysis in both groups were significantly better than those before dialysis(all P＜0.05),and the levels of blood phosphorus,iPTH and bone alkaline phosphatase in the experimental group were significantly better than those in the control group at each time period,with a statistically significant difference(all P＜0.05).Serum calcium was posi-tively correlated with iPTH(r=0.931,P=0.023),while serum phosphorus and bone alkaline phos-phatase were negatively correlated with iPTH(r=-1.654,-0.796,P＜0.05).Blood calcium,phosphorus and bone alkaline phosphatase were the influencing factors of iPTH(all P＜0.05).The survival rate of the experimental group was significantly higher than that of the control group(P＜0.05).Conclusions High-flux hemodialysis can effectively reduce blood phosphorus level and bone alkaline phosphatase level,and then effectively control the level of iPTH.
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万方数据
维普
