Clinical diagnosis and treatment of 52 children with disorder of sex development
Objective To analyze the clinical characteristics of diagnosis and treatment of dis-order of sex development(DSD)in children,and further improve the diagnosis and treatment of DSD.Methods The clinical data of 52 inpatients with DSD of Urology of Hunan Children's Hospital from January 2019 to November 2021 were retrospectively analyzed,summarize and analyze the characteristics of clinical diagnosis and treatment.The patients were divided into group A(46,XX DSD,11 cases),group B(46,XY DSD,20 cases)and group C(sex chromosome DSD,21 cases),and the clinical di-agnosis and treatment characteristics were summarized and analyzed.Results The age of group C was less than that of groups A and B,and the difference was statistically significant(P＜0.05).The rate of no gonadal biopsy and vaginal uterus in group A was higher than that in group B and C,the rate of gonadal pathology was testicular tissue and the rate of prostate sac in group B was higher than that in group A and C.The difference was statistically significant(P＜0.001).Group A:9 cases were gen-der identified,including 2 cases of urethroplasty,1 case of quasi-adolescent vaginoplasty,4 cases of glucocorticoid therapy+clitoridplastic surgery,1 case of glucocorticoid therapy+quasi-adolescent vaginoplasty and clitoridplastic surgery.Group B:There were 13 cases of gender identification,inclu-ding 5 cases of gender change,all of which were female to male,including 8 cases of urethroplasty,1 case of ootestectomy+urethroplasty,1 case of ootestectomy+prostatic cyst resection+urethroplasty,1 case of bilateral gonadectomy+clitoridectomy,and 1 case of bilateral gonadectomy+growth hormone therapy.Group C:19 cases of gender identification,11 cases of urethroplasty,3 cases of mixed gona-dectomy+pelvic cystic mass resection+urethroplasty,2 cases of bilateral gonadectomy+clitoridecto-my,3 cases of mixed gonadectomy+urethroplasty.Conclusions Individualized treatment under multidisciplinary diagnosis and treatment mode can provide comprehensive,whole-process and effective diagnosis and treatment ideas for children with disorder of sex development,which is worth promoting.
ChildSexual DevelopmentMultidisciplinary Diagnosis and Treatment
万方数据
维普
