Analysis of the outcome and safety of assisted reproduction in patients with severe oligonasthe-nospermia
Objective To investigate the outcome and safety of assisted reproduction in patients with severe oligonasthenospermia.Methods The clinical data of 366 patients with severe oligonastheno-spermia who received intracytoplasmic single sperm injection(ICSI)treatment(severe oligonastheno-spermia group,183 cases)and patients with obstructive azoospermia who underwent percutaneous epi-didymal sperm aspiration(PESA)sperm retrieval(control group,183 cases)were selected from Sep-tember 2015 to December 2019 in our hospital.The normal fertilization rate,normal cleavage rate,a-vailable embryo rate,superior embryo rate,female pregnancy outcome,neonatal outcome and birth de-fect were compared between the two groups.Results The implantation rate,pregnancy rate,and rate of available embryos in the severe oligonasthenospermia group were lower than those in the control group,and the differences were all statistically significant(all P＜0.05).The normal fertilization rate and the rate of high-quality embryos in the severe oligonasthenospermia group were lower than those in the control group,while the rate of normal cleavage was higher than that in the control group,and none of the differences was statistically significant(all P＞0.05).There were 114 clinical pregnancies and 104 de-liveries in the severe oligonasthenospermia group,while there were 132 clinical pregnancies and 118 de-liveries in the control group.In terms of the comparison of miscarriage rate,ectopic pregnancy rate and twin pregnancy rate between the two groups,the differences were not statistically significant(all P＞0.05).In the severe oligonasthenospermia group,there were 76 live births in 76 singleton births and 56 live births in 28 twin births.In the control group,there were 83 live births in 83 singleton births and 70 live births in 35 twin births.There was no statistical significance in the natural delivery rate,premature birth rate,low birth weight infants,and sex ratio(male/female)between the two groups in the single and twin delivery cycles(all P＞0.05).One neonate of patients in the severe oligohydramnios group had a depressed left external auricle.There were no newborns with birth defects in the control group,and the difference was not statistically significant(P＞0.05).Conclusions Compared with patients with ob-structive azoospermia,patients with severe oligonasthenospermia have a low rate of available embryos,implantation,and pregnancy in fresh embryo transfers,but there are no differences in post-pregnancy and neonatal conditions between the two groups,which are reliable and safe up to the birth stage.
万方数据
维普
