Influence of hemoperfusion combined with hemodialysis on renal anemia,micro-inflammatory state and oxidative stress in patients with uremia
Objective To investigate the hemoperfusion combined with hemodialysis on renal anemia,micro-inflammatory state and oxidative stress in patients with uremia.Methods The clinical data of 52 patients with chronic renal failure receiving maintenance hemodialysis treatment in the Fifth People's Hospital of Wuhu City from January 2020 to December 2021 were retrospectively analyzed,and the patients were randomly divided into treatment group(receiving hemoperfusion combined with hemodialysis treatment)and control group(receiving pure hemodialysis treatment),with 26 cases in each group.The levels of pre-treatment hemoglobin(Hb),tumor necrosis factor-a(TNF-α)and in-terleukin-6(IL-6)and the oxidation products malondialdehyde(MDA)and reactive oxygen species(ROS)were compared.Results The Hb level of patients in the treatment group was higher than that before treatment(t=8.23,P＜0.001),and was higher than that of patients in the control group dur-ing the same period,and the difference was statistically significant(t=7.89,P＜0.001).The TNF-α level of patients in the treatment group was significantly lower than that at baseline(t=15.48,P＜0.001),and was significantly lower than the level of patients in the control group during the same pe-riod(t=19.16,P＜0.001).The level of IL-6 in the treatment group decreased significantly com-pared with that before treatment(t=14.08,P＜0.001).The ROS level of patients in the treatment group after 12 weeks of treatment was significantly lower than that before treatment(t=21.79,P＜0.001),which was significantly lower than the level of patients in the control group during the same period(t=22.90,P＜0.001).The ROS level of patients in the control group was lower than that be-fore treatment.The ROS levels of patients in the control group had no significant change compared with before treatment(t=1.85,P=0.071).The MDA level in the treatment group after 12 weeks of treat-ment was significantly lower than before treatment(t=20.16,P＜0.001).Conclusions Hemoperfu-sion combined with hemodialysis treatment can better improve the anemia of uremia patients and make the patient's hemoglobin reach the standard,which may be related to the hemoperfusion series hemodi-alysis can reduce the microinflammation and oxidative stress status in maintenance hemodialysis pa-tients.
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