同型半胱氨酸与β2微球蛋白联合检测对H型高血压肾损害的临床预测价值
The clinical prediction value of homocysteine combined with β2 microglobulin in patients with H-type hypertension
周红艳 1赵婧 1赵丽梅2
作者信息
- 1. 唐山市中心血站检验科,唐山 063000
- 2. 唐山市妇幼保健院检验科,唐山 063000
- 折叠
摘要
目的 探讨同型半胱氨酸(Hey)与β2微球蛋白(β2-MG)联合检测预测H型高血压肾损害的临床价值.方法 回顾性选取2021年2月至2023年2月在唐山市妇幼保健院就诊的130例H型高血压患者、130例单纯性高血压患者及130例健康体检人员为研究对象,分别设为H型高血压组、单纯性高血压组及健康对照组.分析三组研究对象的血清Hey水平与年龄、血清胱抑素C(Cys C)、尿β2-MG水平的相关性,采用多元线性回归分析影响血清Hey水平的相关因素.结果 H型高血压组患者的年龄高于单纯性高血压组、健康对照组,血清Hcy、Cys C、尿β2-MG水平均高于单纯性高血压组、健康对照组,差异均有统计学意义(均P＜0.05).血清Hey水平与血清Cys C、尿β2-MG水平均呈显著正相关(均P＜0.05).多元线性回归分析结果显示,年龄、CysC、尿β2-MG是血清Hey水平的影响因素(均P＜0.05).结论 同型半胱氨酸(Hey)与β2-MG联合检测预测H型高血压肾损害的临床价值较高.
Abstract
Objective To investigate the clinical value of homocysteine(Hcy)combined with beta 2-microglobulin(β2-MG)in the prediction of renal damage in H-type hypertension.Meth-ods A total of 130 patients with H-type hypertension,130 patients with simple hypertension and 130 healthy physical examination personnel who were treated in Tangshan Maternal and Child Health Hospi-tal from February 2021 to February 2023 were retrospectively selected as the study objects,and were set as H-type hypertension group,simple hypertension group and healthy control group,respectively.The correlation between serum Hcy level and age,serum Cys C and urinary β2-MG levels of was ana-lyzed,and the influencing factors of serum Hcy level were analyzed by multiple linear regression.Results The age of H-type hypertension group was higher than that of three groups simple hyperten-sion group and healthy control group,and the levels of serum Hcy,Cys C and urinary β2-MG were higher than those of simple hypertension group and healthy control group,with statistical significance(all P＜0.05).Serum Hcy level was positively correlated with serum Cys C and urinary β2-MG levels(all P＜0.05).Multiple linear regression analysis showed that the influence factors of serum Hcy lev-el included age,Cys C and urinary β2-MG(all P＜0.05).Conclusions The combined determina-tion of homocysteine(Hcy)and β2-microglobulin(β2-MG)is of high clinical value in the prediction of renal damage in H-type hypertension.
关键词
高血压/肾损害/同型半胱氨酸/β2微球蛋白Key words
Hypertension/Renal Injury/Homocysteine/beta 2-Microglobulin引用本文复制引用
基金项目
河北省卫生健康委科研项目(20221839)
出版年
2024
NETL
NSTL
万方数据