Effects of transurethral holmium laser resection on miR-119a,miR-200b and inflammatory fac-tors in patients with high-risk non-muscular invasive bladder cancer
Objective To investigate the effects of tranthral holmium laser resection(HOL-ERBT)on miR-119a,miR-200b and inflammatory factors in patients with high-risk non-muscular in-vasive bladder cancer(NMIBC).Methods A total of 82 high-risk NMIBC patients admitted to hospi-tal from January 2016 to January 2021 were retrospectively selected as the observation objects.They were divided into study group(41 cases)and control group(41 cases)according to the surgical method.The study group received HOL-ERBT treatment,while the control group received transurethral resection of bladder tumor(TURBT)treatment.The levels of microRNA-119a(miR-119a),microRNA-200b(miR-200b),inflammatory factors[tumor necrosis factor α(TNF-α),interleukin-6(IL-6),high mobility group protein 1(HMGB1)],pathologic staging accuracy and perioperative indexes were com-pared between the two groups before and after surgery(intraoperative blood loss and duration of contin-uous bladder irrigation,catheter indentation,surgery,and hospital stay),incidence of complications(blood clot accumulation,bladder spasm,bladder perforation,obturator nerve reflex),and follow-up(survival,metastasis,and recurrence).Results Before operation,there were no significant differ-ences in the levels of miR-119a,miR-200b,TNF-α,IL-6 and HMGB1 between two groups(all P＞0.05).Compared with pre-operation,the level of miR-119a was lower after operation 3 months,and the levels of miR-200b and TNF-α,IL-6 and HMGB1 were higher in both groups,with significant differences(all P＜0.01).However,there was no statistical significance in miR-119a and miR-200b levels between the two groups(all P＞0.05).The levels of TNF-α,IL-6,HMGB1,intraoperative blood loss,complication rate,metastasis rate and recurrence rate 2 years after operation in the study group were lower than those in the control group,and the duration of continuous bladder irrigation,catheter retention and hospital stay were shorter than those in the control group,the differences were significant(all P＜0.05).Conclusions In the treatment of high-risk NMIBC,HOL-ERBT has better efficacy than TURBT,which can reduce the inflammatory response of patients,reduce the risk of tumor metastasis,recurrence and complications,and promote rapid recovery with less surgical trauma.
NETL
NSTL
万方数据
