Expression levels of HoxB3 and JAG1 in renal cell carcinoma tissues and their effects on clinical prognosis
Objective To explore the expression levels of homeobox gene B3(HoxB3)and JAG1 in renal cell carcinoma tissues and their effects on clinical prognosis.Methods A total of 93 patients with renal cell carcinoma admitted to our hospital from January 2017 to January 2020 were se-lected as the observation group,and the cancer tissue specimens of renal cell carcinoma patients(renal cell carcinoma group)and the corresponding paracancerous tissue specimens(paracancerous group)were collected.Immunohistochemistry was used to detect the expression levels of HoxB3 and JAG1 in renal cell carcinoma tissues and adjacent tissues.The relationship between the expression of HoxB3 and JAG1 and the clinicopathological characteristics of patients with renal cell carcinoma was analyzed.Multivariate Cox regression was used to analyze the related factors affecting the prognosis of patients with renal cell carcinoma.Results The positive expression rate of HoxB3 in renal cell carcinoma group was lower than that in paracancerous group,and the positive expression rate of JAG1 was higher than that in paracancerous group(all P＜0.001).A total of 62 patients survived,with a survival rate of 66.67％.The HoxB3 positive expression rate and JAG1 negative expression rate in renal cell carci-noma patients with poorly differentiated,TNM stage Ⅲ-Ⅳ,Fuhrman grade Ⅲ-Ⅳ,lymph node metas-tasis and renal envelope invasion were lower than those in middle/highly differentiated renal cell carci-noma patients with TNM stage Ⅰ-Ⅱ,Fuhrman grade Ⅰ-Ⅱ,no lymph node metastasis and renal en-velope invasion,and the 3-year survival rate was higher than that of patients with poorly differentiated renal cell carcinoma,TNM stage Ⅲ-Ⅳ,Fuhrman grade Ⅲ-Ⅳ,lymph node metastasis,renal enve-lope invasion,HoxB3 negative expression and JAG1 positive expression(all P＜0.05).The 3-year survival rate of patients with HoxB3 positive expression and JAG1 negative expression was higher than that of patients[28(80.00％)vs.34(58.62％),18(85.71％)vs.44(61.11％),all P＜0.05].TNM stage Ⅲ-Ⅳ,lymph node metastasis,negative expression of HoxB3 and positive expression of JAG1 were risk factors for prognosis of patients with renal cell carcinoma(all P＜0.05).Conclusions The expression of HoxB3 is low in renal cell carcinoma,and JAG1 is high in renal cell carcinoma.Both of them are closely related to the clinicopathological characteristics and prognosis of patients with renal cell carcinoma,and can be used as biological markers for the prognosis evaluation of renal cell carcinoma.
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