Efficacy of mirabegron combined with tamsulosin in the treatment of ureteral-related symptoms
Objective To evaluate the efficacy of mirabelone combined with tamsulosin on u-reteral-related symptoms by ureteral stent symptom questionnaire(USSQ).Methods A total of 226 patients with ureteral stenting admitted to our hospital from April 2020 to November 2021 were selected as the study objects.The patients were randomly divided into control group(75 cases),mirabelone group(50 mg/d,75 cases),and mirabelone group(50 mg/d)+tamsulosin group(0.2 mg/d)(76 cases).Before stent removal,all patients completed the Chinese version of the USSQ.USSQ and post-operative complications of the three groups were observed and analyzed.Results Urinary symptoms,body pain,general health and other problems in the mirabegron group were better than those in the control group,while the USSQ scores in the mirabegron+tamsulosin group were better than those in the control group(all P＜0.05).Mirabegron+tamsulosin group had better urination symptoms and body pain than mirabegron group,and the differences were statistically significant(all P＜0.05).There were 2 cases of dry mouth,1 case of acute urinary retention and 1 case of tachycardia in mirabe-gron group.There were 3 cases of dry mouth,1 case of anaphylaxis and 1 case of postural hypotension in the mirabegron+tamsulosin group.There were no adverse reactions such as constipation and tachy-cardia.Conclusions The application of mirabegron alone can significantly improve ureteral-related symptoms.The mirabegron+tamsulosin combination therapy can achieve better results without increas-ing adverse reactions.
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