前列腺癌根治术后胱抑素C、β2微球蛋白的临床意义
Clinical significance of cystatin C and β2-microglobulin in radical prostatectomy
郭毛毛 1许志斌 1卞浩 1王江平 1夏园2
作者信息
- 1. 南京医科大学附属泰州人民医院泌尿外科,泰州 225300
- 2. 南京医科大学附属泰州人民医院血液科,泰州 225300
- 折叠
摘要
目的 探讨胱抑素C(CysC)、β2微球蛋白(β2-MG)对前列腺癌根治术后的临床意义.方法 回顾性分析2019年1月至2021年1月本院收治的63例行前列腺癌根治术患者的临床资料,所有患者分别于手术前、手术后1、3、6、12个月行胱抑素C和β2微球蛋白检测,分析胱抑素C及β2微球蛋白水平与前列腺癌根治术后肿瘤负荷的相关性.结果 术后3、6、12个月的Cys C较术前均明显下降,差异均有统计学意义(均P＜0.05);术后1、3、6个月患者的β2-MG较术前下降,差异均有统计学意义(均P＜0.05).结论 CysC、β2-MG可作为前列腺癌根治术后疗效的重要监测指标,可成为前列腺癌中判断肿瘤负荷和预后的生物标志物.
Abstract
Objective To investigate the clinical significance of cystatin C(Cys C)and be-ta2-microglobulin(β2-MG)in patients with prostate cancer underwent radical prostatectomy.Methods The clinical data of 63 patients who underwent radical prostatectomy in our center from January 2019 to January 2021 were retrospectively analyzed.The correlation between Cys C and β2-microglobulin levels and tumor burden after radical prostatectomv was analyzed.Results The ()3,6,and 12 months post-operation were significantly lower compared to pre-operation levels,with the differences being statistically significant(all P＜0.05).Similarly,the levels of β2-MG at 1 month,3,and 6 months post-operation were significantly lower than pre-operation levels,also with statistically significant differences(all P＜0.05).Conclusions Cys C and β2-MG can serve as important indica-tors for monitoring the efficacy of radical prostatectomy.Furthermore,they hold potential as biomarkers for assessing tumor burden and prognosis in prostate cancer.
关键词
前列腺肿瘤/胱抑素C/β2微球蛋白/前列腺切除术Key words
Prostatic Neoplasms/Cystatin C/Beta 2-Microglobulin/Prostatectomy引用本文复制引用
基金项目
泰州市人民医院院级科研基金(ZL202203)
南京医科大学泰州临床医学院重点项目(TZKY20230106)
南通大学临床医学专项(2019JQ007)
出版年
2024
NETL
NSTL
万方数据