Evaluation value of miR-216a-5p,S1P,NLR in peritoneal dialysis patients with peritonitis
Objective To evaluate the value of miR-216a-5p,sphingosine 1-phosphate(S1P),neutrophil lymphocyte ratio(NLR)in peritoneal dialysis(PD)patients with peritonitis(PDAP).Methods The medical records of PD patients who came to our hospital from January 2020 to February 2022 were analyzed retrospectively.Twenty-two patients diagnosed as PDAP by peritoneal dialysis fluid bacterial culture were treated as the PDAP group,and 74 patients without PDAP were treated as the non PDAP group.The basic data,peritoneal dialysis fluid white blood cell count(WBC),blood routine examination[calcium,magnesium,phosphorus,potassium content,hemoglo-bin(Hb),serum albumin(ALB)],total cholesterol(TC),triacylglycerol(TG),serum miR-216a-5p,S1P,NLR levels were compared between the two groups.Multivariate logistic regression analysis was used to gradually analyze the risk factors of PDAP patients,and the expression levels of miR-216a-5p,S1P,NLR were analyzed by receiver operating characteristic curve(ROC)for the diagnostic value of PDAP.Results Serum magnesium in the PDAP group was lower than that in the non PDAP group(P＜0.05),and the WBC in peritoneal dialysis fluid was higher than that in the non PDAP group(P＜0.05).Multivariate analysis showed that high miR-216a-5p and high NLR were independent risk factors for the occurrence of PDAP(all P＜0.05),and high S1P was a protective factor for the occur-rence of PDAP(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of PDAP detected jointly by the three groups was 0.991,higher than that detected separately by miR-216a-5p,S1P and NLR(0.879,0.837,0.900),and its specificity was better than that detected a-lone.Conclusions The serum levels of miR-216a-5p,S1P and NLR in patients with PDAP are higher than those in patients without PDAP,and high miR-216a-5p and high NLR are independent risk factors for the occurrence of PDAP,while high S1P is a protective factor for the occurrence of PDAP.The combined detection of miR-216a-5p,S1P and NLR has certain value for the diagnosis of PDAP.
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