Changes and diagnostic value of immune indicators and cytokines in patients with sepsis after PCNL
Objective To analyze the changes and diagnostic value of immune indicators and cytokines in patients with sepsis after percutaneous nephrolithotomy(PCNL).Methods From January 2018 to December 2021,405 patients who underwent PCNL in the hospital were selected,and divided into sepsis group(12 cases)and non-sepsis group(393 cases).CD4+/CD8+,neutrophil-to-lympho-cyte ratio(NLR),soluble triggering receptor expressed on myeloid cells(sTREM-1),interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α)and procalcitonin(PCT)were detected.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of these indicators for sepsis.Results There were more patients with staghorn calculi in the sepsis group than the non-sepsis group(P＜0.05).NLR and sTREM-1 level in the sepsis group were higher than those in the non-sep-sis group(all P＜0.05),and CD4+/CD8+was significantly lower than that in the non-sepsis group(P＜0.05).Serum IL-6,TNF-α and PCT levels in the sepsis group were significantly higher than those in the non-sepsis group(all P＜0.05).The area under the curve(AUC)of combined predic-tion of sepsis after PCNL was 0.996.The sensitivity and specificity of combined prediction were 91.3％and 98.4％.Conclusions NLR,sTREM-1,IL-6,TNF-α and PCT are elevated,while CD4+/CD8+is decreased in patients with sepsis after PCNL.Combinecl testing of these indicators are helpful for clinical early prediction of sepsis after PCNL.
SepsisPercutaneous NephrolithotomyCytokinesImmune Index
NETL
NSTL
万方数据
