Analysis of the relationship between serum YKL-40 and FGF21 levels and dystrophy-inflamma-tory-atherosclerosis syndrome in uremia patients
Objective To investigate the relationship between serum levels of chitinase-3-like protein 1(YKL-40)and fibroblast growth factor 21(FGF21)and malnutrition-inflammation-athero-sclerosis syndrome(MIAS)in patients with uremia.Methods A total of 186 uremia patients admitted to the department of nephrology of our hospital from March 2020 to March 2022 were selected and di-vided into MIAS group(40 cases)and non-MIAS group(146 cases)according to the occurrence of MIAS.Relevant clinical data were collected and serum levels of YKL-40,FGF21,albumin(ALB)and high-sensitivity C-reactive protein(hs-CRP)were detected.Carotid artery ultrasound was used to detect the intima-media thickness(IMT)of the common carotid artery or the branch.Pearson correla-tion analysis of YKL-40,FGF21 and ALB,hs-CRP,IMT.Multivariate logistic regression was used to analyze the risk factors of MIAS in uremia patients,and receiver operating characteristic curve(ROC)was used to analyze the value of YKL-40 and FGF21 in identifying MIAS in uremia patients.Results The levels of serum YKL-40 and FGF21 in MIAS group were higher than those in non-MIAS group(all P＜0.05).Serum YKL-40 and FGF21 levels in MIAS group were positively correlated with hs-CRP and IMT(all P＜0.05),and negatively correlated with ALB(P＜0.05).Prolonged hemodialysis time,high YKL-40 and high FGF21 were risk factors for MIAS in uremia patients(all P＜0.05).The area under the curve of YKL-40 and FGF21 in the identification of MIAS in uremia patients was 0.738 and 0.701,and the area under the curve of combined YKL-40 and FGF21 in the identification of MIAS in uremia patients was 0.933,which was higher than that of single diagnosis(P＜0.05).Conclusions The levels of serum YKL-40 and FGF21 in uremic patients with MIAS increased significantly,which may be related to the occurrence of MIAS.The detection of serum YKL-40 and FGF21 is helpful to as-sess the risk of MIAS.
NETL
NSTL
万方数据
