Evaluation of the effect of neoadjuvant hormone therapy on the"trifecta"of radical surgery for high-risk prostate cancer
Objective To investigate the effects of neoadjuvant hormonal therapy(NHT)on the"trifecta"outcomes post-radical prostatectomy(RP)in high-risk prostate cancer patients.Meth-ods A retrospective analysis was conducted on the clinical data of 62 high-risk prostate cancer(PCa)patients who underwent RP in Sichuan Cancer Hospital from May 2015 to March 2022.Among them,31 patients received NHT as the neoadjuvant group,while the remaining 31 patients who underwent RP without NHT served as the control group.Perioperative conditions,tumor control,urinary function re-covery,and postoperative sexual function were compared between the two groups.Results The neoad-juvant group had a significantly lower positive margin rate and a higher pathologic downstaging rate compared to the control group,with statistically significant differences(all P＜0.05).There were no statistically significant differences observed in the recovery time of urinary continence,sexual function,and biochemical relapse-free rates between the two groups immediately after surgery,as well as at 3,6,and 12 months post-surgery(all P＞0.05).Conclusions Neoadjuvant hormonal therapy can sig-nificantly reduce positive surgical margins and achieve pathologic downstaging,leading to complete pathologic remission in some patients.It offers clear benefits in tumor control and is a viable treatment option for high-risk PCa patients.
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