The relationship between the expression of CNN1 and ACTG2 in prostate cancer tissues and the pathological characteristics and prognosis of patients
Objective To explore the relationship between the expression of calmodulin 1(CNN1),smooth muscle actin γ2(ACTG2)and the pathological features and prognosis of patients with prostate cancer.Methods A total of 98 patients with prostate cancer admitted to Qionghai Hospi-tal of Traditional Chinese Medicine from December 2016 to December 2019 were selected as the obser-vation group,and the cancer tissue specimens(prostate cancer group)and corresponding paracancer-ous tissue specimens(paracancerous group)of patients with prostate cancer were collected.The ex-pression levels of CNN1 and ACTG2 in prostate cancer tissues and adjacent tissues were detected by immunohistochemistry.The relationship between CNN1 and ACTG2 expression and clinicopathological characteristics of prostate cancer patients were analyzed.Multivariate Cox regression was used to ana-lyze the risk factors affecting the prognosis of patients with prostate cancer.Results The positive ex-pression rates of CNN1 and ACTG2 in prostate cancer group were lower than those in adjacent cancer group(all P＜0.01).Gleason score was 8-10,clinical stage was T2-3,preoperative serum prostate-specific antigen(PSA)≥4 μg/L,the positive expression rates of CNN1 and ACTG2 in μg/L patients with lymph node metastasis and distant metastasis were lower than those in patients with Gleason score(2-7 scores),clinical stage(T1),preoperative serum PSA＜4 μg/L,no lymph node metastasis and no distant metastasis(all P＜0.05).The 3-year survival rate of CNN1 positive expression patients was 79.41％,which was higher than that of CNN1 negative expression patients 57.81％(P＜0.05).The 3-year survival rate of ACTG2-positive patients was 79.17％,which was higher than that of ACTG2-negative patients(52.00％)(P＜0.05).The 3-year survival rate of prostate cancer patients with Gl-eason score of 2 to 7,clinical stage T1,preoperative serum PSA＜4 μg/L,no lymph node metastasis and no distant metastasis was higher than that of patients with Gleason score of 8 to 10,clinical stage of T2 to T3,preoperative serum PSA≥4 μg/L,lymph node metastasis and distant metastasis(all P＜0.05).Multivariate Cox regression analysis showed that Gleason score was 8-10 scores(HR=2.447,95％CI:1.599-3.745),lymph node metastasis was present(HR=2.514,95％CI:1.676-3.772),and CNN1 expression was negative(HR=5.795,95％CI:2.964-11.328)and negative expression of ACTG2(HR=2.912,95％CI:1.823-4.653)were prognostic risk factors for prostate cancer patients(all P＜0.05).Conclusions CNN1 and ACTG2 are lowly expressed in prostate cancer patients and are related to clinicopathological features and prognosis,which can be used as biological markers for the prognosis evaluation of prostate cancer.
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