Diagnostic value of DWI combined with serum WISP1 and FOXO3a for preoperative lymph node metastasis of bladder cancer
Objective To explore the diagnostic value of diffusion-weighted imaging(DWI)combined with serum Wnt1 induced secretory protein 1(WISP1)and forkhead box transcription factor O subgroup 3a(FOXO3a)for preoperative lymph node(LN)metastasis of bladder cancer(BC).Methods A retrospective analysis was performed on 185 suspected BC patients admitted to our hospi-tal from March 2020 to March 2022,104 patients diagnosed as BC by pathology were in the BC group,68 patients with LN metastasis were in the LN group,and 36 patients without LN metastasis were in the non LN group.At the same time,98 healthy volunteers in our hospital served as the control group.The expression of WISP1 and FOXO3a in serum was detected by enzyme-linked immunosorbent assay(ELISA).Pearson method was used to analyze the correlation between WISP1 and FOXO3a in serum of BC patients.The ROC curve was drawn to analyze the diagnostic value of DWI combined with serum WISP1 and FOXO3a for preoperative LN metastasis of BC.Results Compared with the control group,the expression level of WISP1 in serum of BC patients was obviously increased,and the expression lev-el of FOXO3a was obviously decreased(all P＜0.001).Compared with the non LN group,patients in the LN group showed a significant increase in WISP1 expression levels and a significant decrease in FOXO3a expression levels(all P＜0.001).The results of correlation analysis showed that the expres-sion levels of serum WISP1 and FOXO3a in BC patients were negatively correlated(r=-0.346,P＜0.001).Compared with the group without LN,the ADC value of patients in the LN group was signifi-cantly reduced(P＜0.05).The sensitivity of DWI combined with serum WISP1 and FOXO3a in diag-nosing LN metastasis before BC was higher than that of DWI,serum W1SP1 and FOXO3a alone(P＜0.05).Conclusions The expression level of WISP1 in serum of patients with LN metastasis before BC is obviously increased,and the expression level of FOXO3a is obviously decreased.DWI combined with serum WISP1 and FOXO3a can improve the diagnostic efficacy for preoperative LN metastasis of BC.
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