Clinical significance of NLR and IL-10 levels in patients with bladder cancer and prediction of tumor recurrence within 1 year after surgery
Objective To observe the clinical significance of peripheral blood neutrophil-lym-phocyte ratio(NLR)and urine interleukin-10(IL-10)expression in patients with bladder cancer and its predictive effect on recurrence within one year after operation.Methods The clinical data of 112 patients with bladder cancer admitted to our hospital from January 2019 to January 2021 were selected.Before treatment,the baseline data of patients were recorded in detail,and the levels of NLR in pe-ripheral blood and IL-10 in urine were detected.Laparoscopic radical cystectomy was performed.The patients were followed up for 8-12 months to evaluate the tumor recurrence,and were divided into the recurrence group(22 cases)and the non recurrence group(90 cases).The baseline data,peripheral blood NLR and urine IL-10 levels were compared between the two groups.Regression analysis was used to examine the relationship between peripheral blood NLR and urine IL-10 levels and tumor recur-rence within 1 year after surgery in bladder cancer patients.The predictive efficacy of peripheral blood NLR and urine IL-10 levels on recurrence within 1 year after surgery were analyzed.Results The proportion of low differentiation,concurrent lymph node metastasis,peripheral blood NLR,and urine IL-10 levels in the recurrence group were higher than those in the non recurrence group(all P＜0.05).Logistic regression analysis showed that poor differentiation,lymph node metastasis,high lev-els of peripheral blood NLR and urine IL-10 were risk factors for tumor recurrence in bladder cancer patients within one year after surgery(OR＞1,all P＜0.05).The area under the curve(AUC)of the peripheral blood NLR and urine IL-10 levels in patients with bladder cancer to predict tumor recurrence after surgery individually and jointly were all higher than 0.80.There was no statistical significant difference in NLR and IL-10 levels between patients with different degrees of differentiation,with and without lymph node metastasis(all P＞0.05).Conclusions Patients with bladder cancer have a high risk of recurrence within one year after operation,which is correlated with tumor differentiation,lymph node metastasis,peripheral blood NLR and urine IL-10 levels.Among them,peripheral blood NLR and urine IL-10 levels can be used as predictive indicators of tumor recurrence after surgery.
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