The relationship between the expression levels of PBX1 and MEIS2 and the clinical manifesta-tions and prognosis of patients with renal cell carcinoma
Objective To explore the relationship between the expression levels of preB-cell leukemia transcription factor 1(PBX1)and MEIS2 and the clinical manifestations and prognosis of pa-tients with renal cell carcinoma(RCC).Methods Ninety-six patients with RCC treated in our hospi-tal from May 2017 to May 2020 were selected as the study objects.Cancer tissue specimens were included in the RCC group(96 cases),and corresponding paracancer tissue specimens were included in the para-cancer group(96 cases).The expression of PBX1 and MEIS2 in tissues was detected by immunohistochemical method.The relationship between the expression of PBX1 and MEIS2 and the clinicopathological features of RCC patients was analyzed.The prognostic factors of RCC patients were investigated by multivariate Cox regression analysis.Results The positive expression rates of PBX1 and MEIS2 in RCC group were higher than those in para-cancer group[75.00％(72/96)vs.34.38％(33/96),71.88％(69/96)vs.40.63％(39/96),allP＜0.001].The PBX1 positive expression rate and MEIS2 positive expression rate in patients with RCC stage Ⅲ,WHO/ISUP grade 3/4,and lymph node metastasis were higher than those with RCC stage Ⅰ/Ⅱ,WHO/ISUP grade 1/2,and no lymph node metastasis(all P＜0.05).The 3-year overall survival rate of patients with RCC stage Ⅰ/Ⅱ,WHO/ISUP grade 1/2,no lymph node metastasis,negative PBX1 and negative MEIS2 was higher than that of patients with RCC stage Ⅲ,WHO/ISUP grade 3/4,lymph node metastasis,positive PBX1 and positive MEIS2(all P＜0.05).Multivariate Cox regression analysis showed that the clini-cal stage Ⅲ(HR=2.389,95％CI:1.444-3.954),PBX1(HR=3.699,95％CI:1.941-7.049),MEIS2(HR=4.145,95％CI:1.885-9.115)were prognostic factors in RCC patients(all P＜0.05).Conclusions PBX1 and MEIS2 are highly expressed in the cancer tissues of RCC patients,which are closely related to the clinical stage and differentiation degree of RCC,and can be used as potential markers to assist in evaluating the prognosis of patients.
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