Relationship between PCT,IL-6,IL-8,IFN-γ and urinary tract infection in urology patients
Objective To investigate the relationship between catheter-associated urinary tract infection(CAUTI)and serum levels of procalcitonin(PCT),interleukin-6(IL-6),interleukin-8(IL-8)and interferon γ(IFN-γ)in urology patients.Methods From March 2019 to July 2020,135 patients were treated with catheter-assisted therapy in our hospital were selected and divided into con-trol group(84 cases)and infection group(51 cases)according to the occurrence of related urinary tract infection.The serum levels of PCT,IL-6,IL-8 and IFN-γ were compared between the two groups;The correlation between PCT,IL-6,IL-8,IFN-γ levels and CAUTI in urology patients was analyzed.Re-ceiver operating characteristic curve(ROC)was plotted to compare the diagnostic value of combined diagnosis for CAUTI in urology patients.Univariate analysis of the factors influencing CAUTI in urology patients.Binary logistic regression analysis of independent risk factors for CAUTI in urology patients.Results Compared with control group,the serum levels of PCT,IL-6,IL-8 and IFN-γ in infected group were significantly increased(all P＜0.05).Spearman correlation coefficient analysis showed that PCT,IL-6,IL-8 and IFN-γ levels were positively correlated with CAUTI in urological patients(all P＜0.001).ROC curve showed that the area under the curve of combined diagnosis of four inde-xes was higher than that of combined diagnosis of two indexes(P＜0.05).Univariate analysis showed that CAUTI was affected by catheter retention time,antibiotic use,PCT,IL-6,IL-8 and IFN-γ levels(all P＜0.05).The results of multivariate analysis showed that catheter retention duration≥8 d,PCT≥3.98 ng/mL,IL-6≥15.42 pg/mL,IL-8≥116.34 pg/mL,IFN-γ ≥26.63 ng/mLwere inde-pendent risk factors for CAUTI in urological patients.The use of antibiotics was a protective factor(all P＜0.05).Conclusions The changes of PCT,IL-6,IL-8 and IFN-γ levels are positively correlated with CAUTI in urology patients.Timely detection of these indicators during admission to urology is conducive to early detection of urinary tract infection in patients,so as to take appropriate measures,which has important clinical significance.
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