Diagnostic value of serum procalcitonin and serum amyloid A protein in infants with urinary tract infection to bladder and ureteral reflux
Objective To detect serum procalcitonin(PCT),serum amyloid A protein(SAA)level in infants with urinary tract infection(UTI)and to analyze both and the diagnostic value of vesi-coureteral reflux(VUR).Methods A total of 118 children with UTI admitted to the Affiliated Hospi-tal of Yan'an University from February 2016 to December 2018 were selected as the study objects,and were divided into UTI group(70 cases)and UTI combined VUR group(48 cases)according to wheth-er they had VUR.According to the International Children's Reflux Association classification system,the children with VUR were divided into low-grade reflux group(20 cases)and high-grade reflux group(28 cases).The level of serum PCT was detected by automatic chemiluminescence instrument,the level of SAA was detected by PA600 lifotronic protein analyzer,and the levels of serum urea nitro-gen(BUN),creatinine(Scr)and urinary albumin(Alb)were detected by automatic biochemical an-alyzer.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum PCT level for UTI combined with VUR,and logistic regression analysis was performed on the re-lated factors affecting the occurrence of VUR.Results The levels of serum PCT and SAA in UTI com-bined VUR group were higher than those in UTI group(all P＜0.05).The levels of serum PCT and SAA in high-grade reflux group were higher than those in low-grade reflux group(all P＜0.05).Ser-um PCT level predicted VUR with a cut-off of 0.89 ng/mL,sensitivity of 70.80％,specificity of 90.00％,and area under the curve(AUC)of 0.872(95％CI:0.810-0.935,P＜0.05),the thresh-old value of serum SAA for predicting VUR was 235.58 mg/L,the sensitivity was 72.90％,the speci-ficity was 54.20％,and the AUC was 0.732(95％CI:0.639-0.825,P＜0.05),the sensitivity and specificity of serum PCT combined with SAA to predict VUR were 85.40％,87.10％,and AUC were 0.906(95％CI:0.851-0.961,P＜0.05).High levels of serum PCT and SAA were risk factors for VUR in children with UTI(all P＜0.05).Conclusions The serum PCT level in UTI combined VUR group is significantly higher than that in UTI group,PCT and SAA levels have certain diagnostic value for UTI combined with VUR and could be used as auxiliary examination indexes in the diagnosis of UTI combined with VUR.
Urinary Tract InfectionsProcalcitoninSerum Amyloid A ProteinVesico-Ureteral Reflux
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NSTL
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