The diagnostic efficacy of serum IDO1 and β-catenin levels on coronary vascular calcification in non-dialysis patients with chronic kidney disease
Objective To explore the diagnostic efficacy of serum indoleamine 2,3-dioxygen-ase-1(IDO1)and β-catenin levels for vascular calcification in non-dialysis patients with chronic kid-ney disease(CKD).Methods A total of 106 non-dialysis patients with CKD admitted to Chenzhou First People's Hospital from January 2021 to December 2022 were selected as study group,and 100 healthy people admitted to hospital during the same period were selected as the control group.Serum levels of IDO1 and β-Catenin were detected by enzyme-linked immunosorbent assay.Patients in study group were classified into non-calcification group(67 cases)and calcification group(39 cases)based on the results of coronary artery calcification scores(CACs).The levels of serum IDO1 and β-catenin in all subjects were compared.ROC was used to evaluate the diagnostic value of serum IDO1 and β-catenin levels for vascular calcification in non-dialysis patients with CKD.Multivariate logistic regres-sion analysis was used to investigate the factors affecting vascular calcification in non-dialysis patients with CKD.Results Serum IDO1 level in the study group was lower than that in the control group,andβ-catenin level was higher than that in the control group(all P＜0.001).The level of serum IDO1 in the calcification group was lower than that in the control group,and and β-catenin level was higher than than in the non-calcification group(all P＜0.001).The AUC of serum IDO1 and β-catenin pre-dicting vascular calcification in non-dialysis CKD patients was 0.751(95％CI:0.706-0.819)and 0.835(95％CI:0.785-0.877),respectively,and the AUC predicted by the combination of the two was 0.906(95％CI:0.861-0.958).The diabetes history,number of CKD stages(3-5 stages),blood calcium,blood phosphorus,blood potassium and albumin values in calcification group were higher than those in non-calcification group(all P＜0.05).CKD stages,IDO1 and β-catenin were the influential factors for vascular calcification in non-dialysis patients with CKD(all P＜0.05).Con-clusions Serum IDO1 level decreased and β-catenin level increased in CKD non-dialysis patients with coronary artery calcification,and the combination of the two may be used as biomarkers for the diagno-sis of coronary artery calcification in CKD non-dialysis patients.
NETL
NSTL
万方数据
