Mir-217/Sirt1通路与糖尿病肾病
Mir-217/Sirt1 pathway and diabetic nephropathy
邵滢 1王秋月1
作者信息
- 1. 100011 沈阳,中国医科大学附属第一医院内分泌科
- 折叠
摘要
Mir-217是miRNAs家族的重要成员,在高糖培养的肾小球系膜细胞中表达量升高.Sirt1是一个NAD+调节的脱乙酰酶,既往在衰老性疾病中研究较多,近期发现其在糖尿病肾病中起到抗炎、抗氧化、抗纤维化等保护作用.研究指出,在多种病理条件下mir-217通过直接作用于Sirt1mRNA的3'非翻译区,显著抑制Sirt1蛋白表达,因此mir-217/Sirt1通路可能在糖尿病肾病的发生、发展中起关键作用.
Abstract
Mir-217 is an important member of the miRNAs family overexpressed in high glucose cultured glomerular mesangial cells.Sirt1 is an NAD (+)-dependent deacetylase,which has obtained great focus on the research of aging.Recent researches reported that Sirt1 has protective functions in diabetic nephropathy such as anti-inflammation,anti-oxidance and anti-fibrosis.In a variety of pathological conditions,mir-217 directly acts on the 3 ' translation section of Sirt1 mRNA,and inhibits expression of Sirt1 protein.Thus,mir-217/Sirt1 pathway may play a key role in the occurrence and development of diabetic nephropathy.
关键词
miRNAs/Mir-217/Sirt1/肾脏纤维化/糖尿病肾病Key words
MiRNAs/Mir-217/Sirt1/Renal fibrosis/Diabetic nephropathy引用本文复制引用
基金项目
辽宁省科学技术计划项目(2011225017)
辽宁省百千万人才工程资助项目(2011921037)
出版年
2015
NETL
NSTL
维普
万方数据