MOTS-c是线粒体DNA(mtDNA)短开放阅读框(sORF)编码的小分子多肽，由线粒体12S rRNA编码，作为最新被发现的线粒体衍生肽(MDPs)，是目前研究的热点，其可以改善胰岛素抵抗(IR)预防2型糖尿病(T2DM)；增加棕色脂肪(BAT)产热，促进白色脂肪(WAT)棕色化，以适应寒冷；防止肥胖和脂质代谢紊乱；降低非酒精性脂肪性肝病(NAFLD)的发生率；保护血管内皮细胞，预防冠心病，延缓骨质疏松(OP)。MOTS-c对改善多种代谢相关性疾病的不良结局发挥着积极作用，本文主要围绕MOTS-c与代谢相关性疾病的关系及其作用机理展开综述。 MOTS-c is a small peptide encoded by the short open reading frame(sORF) within mitochondrial DNA(mtDNA), which is encoded by the mitochondrial 12S rRNA. As one of the newly discovered mitochondrial-derived peptides(MDPs), it has emerged as a focal point in research endeavors. MOTS-c has been shown to improve insulin resistance(IR) and prevent type 2 diabetes mellitus(T2DM). Moreover, MOTS-c elicits an augmentation in brown adipose tissue(BAT) thermogenesis and fosters the browning of white adipose tissue(WAT), thereby enabling adaptation to cold environments. It can also prevent obesity and lipid metabolism disorders, reduce the incidence of non-alcoholic fatty liver disease(NAFLD), protect endothelial cells, prevent coronary heart disease, and delay the progression of osteoporosis(OP). MOTS-c plays a positive role in improving the adverse outcome of a variety of metabolic diseases. This paper mainly reviews the function and mechanism of MOTS-c in metabolic-related diseases.
Function and mechanism of MOTS-c in metabolic-related diseases
MOTS-c is a small peptide encoded by the short open reading frame(sORF) within mitochondrial DNA(mtDNA), which is encoded by the mitochondrial 12S rRNA. As one of the newly discovered mitochondrial-derived peptides(MDPs), it has emerged as a focal point in research endeavors. MOTS-c has been shown to improve insulin resistance(IR) and prevent type 2 diabetes mellitus(T2DM). Moreover, MOTS-c elicits an augmentation in brown adipose tissue(BAT) thermogenesis and fosters the browning of white adipose tissue(WAT), thereby enabling adaptation to cold environments. It can also prevent obesity and lipid metabolism disorders, reduce the incidence of non-alcoholic fatty liver disease(NAFLD), protect endothelial cells, prevent coronary heart disease, and delay the progression of osteoporosis(OP). MOTS-c plays a positive role in improving the adverse outcome of a variety of metabolic diseases. This paper mainly reviews the function and mechanism of MOTS-c in metabolic-related diseases.
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