Research progress on the mechanism and noninvasive assessment of vascular endothelial dysfunction in diabetes mellitus
沈诗意 1武晓泓2
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作者信息
1. 浙江中医药大学第二临床医学院，杭州 310053
2. 浙江省人民医院内分泌科，杭州 310014
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摘要
糖尿病(diabetes mellitus)是一种以高血糖为特征的慢性疾病，其患病率在全球范围内不断上升。心血管病变是糖尿病最主要的并发症之一，具有治疗难度大、病情进展快及死亡率高的特征。血管内皮功能受损是诱发糖尿病心血管并发症的始动环节，其持续存在可以作为评估心血管并发症发生风险的一个重要指标。本文综述了糖尿病患者血管内皮功能损伤的机制及无创评估方式研究进展，以期在糖尿病患者中，早期发现并及时干预内皮功能损伤，降低心血管事件的发生风险。 Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia, the prevalence of which is increasing worldwide. Cardiovascular disease is one of the main complication of DM, which is characterized by high treatment difficulty, rapid progression, and high mortality. Vascular endothelial dysfunction is the initiating link in the development of diabetic cardiovascular complications, and its persistence can be an important indicator in assessing the risk of vascular complications. This article reviews the research progress on the mechanism and noninvasive assessment of vascular endothelial dysfunction in patients with DM, with the aim of early detection and timely intervention of endothelial function impairment to reduce the risk of cardiovascular events in patients with DM.
Abstract
Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia, the prevalence of which is increasing worldwide. Cardiovascular disease is one of the main complication of DM, which is characterized by high treatment difficulty, rapid progression, and high mortality. Vascular endothelial dysfunction is the initiating link in the development of diabetic cardiovascular complications, and its persistence can be an important indicator in assessing the risk of vascular complications. This article reviews the research progress on the mechanism and noninvasive assessment of vascular endothelial dysfunction in patients with DM, with the aim of early detection and timely intervention of endothelial function impairment to reduce the risk of cardiovascular events in patients with DM.
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