口服胰岛素被认为是一种更安全和更便捷的糖尿病给药途径，然而受胰岛素自身理化性质和胃肠道屏障的影响，阻碍了口服胰岛素的临床转化。随着新型材料的应用和技术的进步，一些新型载药系统被用于口服胰岛素的给药途径并取得重要进展。本文就口服胰岛素的生理意义及优势，面临的挑战，给药系统，研究现状及未来展望进行综述。 Oral insulin is considered a safer and more convenient route for diabetes administration. However, the clinical translation of oral insulin has been hindered by the physicochemical properties of insulin itself and the gastrointestinal barrier. With the application of new materials and technological advancements, novel drug delivery systems have been used for oral insulin administration and have made significant progress. The article reviews the physiological significance and advantages, challenges, drug delivery system, research status, and future prospects of oral insulin.
Research progress and prospects of oral insulin in the treatment of diabetes
Oral insulin is considered a safer and more convenient route for diabetes administration. However, the clinical translation of oral insulin has been hindered by the physicochemical properties of insulin itself and the gastrointestinal barrier. With the application of new materials and technological advancements, novel drug delivery systems have been used for oral insulin administration and have made significant progress. The article reviews the physiological significance and advantages, challenges, drug delivery system, research status, and future prospects of oral insulin.
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