Changes of Th17 cell ratio and related cytokines in patients with type 2 diabetes mellitus combined with coronary heart disease
Objective To investigate the changes and clinical significance of peripheral blood help-er T cell(Th)17 ratio and its related cytokine expression levels in patients with type 2 diabetes mellitus(T2DM)combined with coronary heart disease.Methods 138 patients with T2DM who attended the De-partment of Cardiology of Department of Cardiology,Tianjin Medical University Chu Hsien-I Memorial Hos-pital and completed coronary angiography(CAG)from February 2021 to June 2022 were selected,including 72 patients in the group of T2DM combined with coronary heart disease,66 patients in the group of T2DM a-lone,and 42 patients who had a healthy physical examination during the same period were selected as the control group.The clinical data and biochemical indexes of the patients were collected,and the peripheral blood Th17 cell ratio and the expression levels of interleukin(IL)-17,IL-6,and IL-23 were detected.SPSS 22.0.software was applied to perform one-way ANOVA,t-test,rank sum test,X2 test,partial correla-tion analysis,and logistic regression analysis.Results The proportion of Th17 cells,and the levels of IL-17,IL-6,and IL-23 in the T2DM combined coronary heart disease group were significantly higher than those in the T2DM group and the control group(all P＜0.05).The proportion of Th17 cells in the T2DM combined coronary heart disease group was positively correlated with the levels of IL-17(r=0.827)and IL-6(r=0.824)(All P＜0.05).Logistic regression analysis showed that the proportion of Th17 cells,IL-17,IL-6 levels,and fasting glucose(FPG)were independent risk factors for coronary heart disease com-plicating T2DM(all P＜0.05).Conclusion Compared with T2DM patients,patients with T2DM com-bined with coronary heart disease may have more severe inflammation,and the proportion of Th17 cells,IL-17,and IL-6 levels may be risk factors for T2DM combined with coronary heart disease.
Type 2 diabetes mellitusCoronary heart diseaseHelper T cell 17Interleukin
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