首页|GLP-1RA治疗阻塞性睡眠呼吸暂停综合征的研究进展

GLP-1RA治疗阻塞性睡眠呼吸暂停综合征的研究进展

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阻塞性睡眠呼吸暂停综合征是一种常见的慢性睡眠障碍,其特征是睡眠时上呼吸道间歇性变窄导致气道部分或完全关闭.肥胖是其发生和恶化的主要因素,患者可合并全身炎症、胰岛素抵抗、2型糖尿病和心血管疾病等,临床上还没有针对该病的治疗药物.胰高血糖素样肽-1受体激动剂不仅可以使这类患者体重下降,还能改善其诸多并发症.本文对胰高血糖素样肽-1受体激动剂在阻塞性睡眠呼吸暂停综合征中的疗效进行综述.
Research progress on the treatment of obstructive sleep apnea syndrome with GLP-1RA
Obstructive sleep apnea syndrome(OSAS)is a common chronic sleep disorder character-ized by episodic narrowing of the upper airway during sleep leading to partial or complete airway closure.0-besity is one of the main factors in its occurrence and deterioration,and patients often have systemic inflam-mation,insulin resistance,type 2 diabetes and cardiovascular disease,etc.However,there is no clinical drug for treating OSAS.Glucagon-like peptide-1 receptor agonists(GLP-1RA)not only perform well in weight loss,but also improve many comorbidities of OSAS.Therefore,this paper reviews the effects of GLP-1RA on OSAS.

Glucagon-like peptide-1 receptor agonistsObstructive sleep apnea syndromeObesity

罗怡、袁璐、马建华

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南京医科大学附属南京医院(南京市第一医院)内分泌科,南京 210012

胰高血糖素样肽-1受体激动剂 阻塞性睡眠呼吸暂停综合征 肥胖

2024

国际内分泌代谢杂志
中华医学会,天津医科大学

国际内分泌代谢杂志

CSTPCD
影响因子:0.842
ISSN:1673-4157
年,卷(期):2024.44(2)
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