Research progress on the role of the liver-α cell axis in diabetes mellitus and fatty liver disease
The liver-α cell axis is a physiological feedback loop involving two main components:glucagon promoting amino acid metabolism and amino acids regulating the proliferation of pancreatic alpha cells and the secretion of glucagon.The liver-α cell axis can simultaneously regulate the metabolism of glu-cose,lipids,and amino acids,and is closely associated with type 2 diabetes mellitus and nonalcoholic fatty liver disease.Clarifying the regulatory role of the liver-α cell axis holds potential as a therapeutic target for the treatment of type 2 diabetes mellitus and nonalcoholic fatty liver disease.
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