肝-胰岛α细胞轴在糖尿病和脂肪肝中的作用研究进展
Research progress on the role of the liver-α cell axis in diabetes mellitus and fatty liver disease
张世璇 1张俊清 1郑佳1
作者信息
- 1. 北京大学第一医院内分泌科,北京 100034
- 折叠
摘要
肝-胰岛α细胞轴是一种生理性反馈环路,主要涉及两个主要环节,包括胰高血糖素促进氨基酸代谢,以及氨基酸调节胰岛α细胞增生和胰高血糖素分泌.肝-胰岛α细胞轴可以同时调控葡萄糖、脂质及氨基酸的代谢,与2型糖尿病及非酒精性脂肪性肝病密切相关.明晰肝-胰岛α细胞轴的调控作用有望为治疗2型糖尿病及非酒精性脂肪性肝病提供潜在的治疗靶点.
Abstract
The liver-α cell axis is a physiological feedback loop involving two main components:glucagon promoting amino acid metabolism and amino acids regulating the proliferation of pancreatic alpha cells and the secretion of glucagon.The liver-α cell axis can simultaneously regulate the metabolism of glu-cose,lipids,and amino acids,and is closely associated with type 2 diabetes mellitus and nonalcoholic fatty liver disease.Clarifying the regulatory role of the liver-α cell axis holds potential as a therapeutic target for the treatment of type 2 diabetes mellitus and nonalcoholic fatty liver disease.
关键词
肝-胰岛α细胞轴/胰高血糖素/2型糖尿病/非酒精性脂肪性肝病Key words
Liver-α cell axis/Glucagon/Type 2 diabetes mellitus/Nonalcoholic fatty liver disease引用本文复制引用
基金项目
国家自然科学基金项目(81800703)
北京市科技新星(Z201100006820117)
北京市科技新星交叉合作课题(20220484181)
出版年
2024
NETL
NSTL
万方数据