Research progress of melanocortin 4 receptor in energy homeostasis and body weight regulation
Obesity is defined as excessive fat accumulation that is harmful to body health,and ener-gy imbalance is its root cause.As a chronic non-communicable epidemic,obesity has become one of the key health problems facing the world.The melanocortin-4 receptor is an important part of the central melanocort-in system,which plays an important role in the maintenance of energy homeostasis and body weight regula-tion,and is one of the hot targets for anti-obesity drug development.Recent studies have greatly enriched the melanocortin-4 receptor signaling pathway.This article reviews the research progress of melanocortin-4 re-ceptor in energy balance and body weight regulation,aiming to further elucidate the obesity-related pathologi-cal mechanisms and provide a theoretical basis for the development of anti-obesity drugs.
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