肾脏免疫球蛋白沉积与糖尿病肾脏病的临床相关性研究
Study on the clinical associations between different types of renal immunoglobulin deposition and dia-betic kidney disease
赵妍 1郭佳欣 2程健 3祁伟 4赵晶晶5
作者信息
- 1. 天津医科大学第二医院内分泌科,天津 300211
- 2. 天津市胸科医院内分泌科,天津 300222
- 3. 中国科学院天津工业生物技术研究所,天津 300308
- 4. 天津医科大学第二医院感染性疾病科,天津 300211
- 5. 天津医科大学第二医院肾内科,天津 300211
- 折叠
摘要
目的 探讨肾脏免疫球蛋白沉积与糖尿病肾脏病(diabetic kidney disease,DKD)的临床相关性.方法 将肾活检确诊为DKD的患者分为4组:(1)一阳(IgA+IgM-IgG-/IgA-IgM+IgG-/IgA-IgM-IgG+).(2)二阳(IgA+IgM+IgG-/IgA+IgM-IgG+/IgA-IgM+IgG+).(3)全阳(IgA+IgM+IgG+).(4)全阴(IgA-IgM-IgG-).收集患者的临床资料,分析肾脏免疫球蛋白沉积与DKD的临床相关性,通过DKD的肾脏终点事件评估其对肾脏预后的预测价值.结果 全阳组患者的尿蛋白定量明显高于其他3组;单因素COX回归分析示全阳组发生肾脏终点事件的风险更高,多因素COX回归分析示免疫球蛋白沉积对肾脏预后无统计学意义.结论 肾脏多种免疫球蛋白沉积增加了 DKD尿蛋白的漏出,但与肾脏预后无明显相关性.
Abstract
Objective To explore the clinical associations between different types of renal immuno-globulin deposition and diabetic kidney disease(DKD).Methods The patients diagnosed as DKD who un-derwent renal puncture biopsy were divided into four groups,which were as follows:(1)One-positive(IgA+IgM-IgG-/IgA-IgM+IgG-/IgA-IgM-IgG+);(2)Two-positive(IgA+IgM+IgG-/IgA+IgM-IgG+/IgA-IgM+IgG+);(3)All-positive(IgA+IgM+IgG+);(4)All-negative(IgA-IgM-IgG-).Clinical data of pa-tients were collected to analyze the clinical correlation between renal immunoglobulin deposition and DKD,and the value of renal endpoint events was assessed to predict renal prognosis in DKD patients.Results The urinary protein quantity of the all-positive group was higher than that of the other three groups.Univari-ate COX regression analysis showed that the risk of renal endpoint events was higher in all-positive groups,while multi-factor COX regression analysis showed that immunoglobulin deposition had no statistical signifi-cance to renal outcome.Conclusion Multiple immunoglobulin deposition in the kidney increased urinary protein leakage in DKD patients,but there was no significant correlation with renal prognosis.
关键词
糖尿病肾脏病/肾脏沉积/免疫球蛋白/肾脏终点事件Key words
Diabetic kidney disease/Renal deposition/Immunoglobulin/Renal endpoint event引用本文复制引用
基金项目
国家自然科学基金(82202578)
天津市科技计划(23YDTPJC00990)
天津市卫生健康委中医中西医结合科研课题(2021077)
天津市教委科研项目(2023ZD003)
天津医科大学第二医院临床医学研究项目(2020LC14)
出版年
2024
NETL
NSTL
万方数据