Study on the clinical associations between different types of renal immunoglobulin deposition and dia-betic kidney disease
Objective To explore the clinical associations between different types of renal immuno-globulin deposition and diabetic kidney disease(DKD).Methods The patients diagnosed as DKD who un-derwent renal puncture biopsy were divided into four groups,which were as follows:(1)One-positive(IgA+IgM-IgG-/IgA-IgM+IgG-/IgA-IgM-IgG+);(2)Two-positive(IgA+IgM+IgG-/IgA+IgM-IgG+/IgA-IgM+IgG+);(3)All-positive(IgA+IgM+IgG+);(4)All-negative(IgA-IgM-IgG-).Clinical data of pa-tients were collected to analyze the clinical correlation between renal immunoglobulin deposition and DKD,and the value of renal endpoint events was assessed to predict renal prognosis in DKD patients.Results The urinary protein quantity of the all-positive group was higher than that of the other three groups.Univari-ate COX regression analysis showed that the risk of renal endpoint events was higher in all-positive groups,while multi-factor COX regression analysis showed that immunoglobulin deposition had no statistical signifi-cance to renal outcome.Conclusion Multiple immunoglobulin deposition in the kidney increased urinary protein leakage in DKD patients,but there was no significant correlation with renal prognosis.
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