Correlation between serum uric acid to creatinine ratio and stability factors of carotid plaque in type 2 diabetes patients
Objective To explore the correlation between the serum uric acid to creatinine ratio(SUA/Cr)and the stability of carotid plaque in patients with type 2 diabetes(T2DM),and to develop a new evaluation scale for rapid clinical evaluation of the stability of carotid plaque in patients with T2DM.Methods 518 inpatients with T2DM and carotid plaque from January 2015 to February 2022 were collect-ed.Collect general information and clinical testing indicators of patients,while improving carotid artery ul-trasound examination.According to the ultrasonic characteristics,the patients were divided into plaque sta-ble group(262 cases)and plaque unstable group(256 cases).The measurement data between the two groups were compared by independent sample t test and Mann-Whitney U test.The counting data were com-pared between the two groups x2 Inspection.The independent risk factors of carotid plaque instability were analyzed by binary logistic regression.Draw the ROC curve for independent risk factors,and calculate the area under the curve(AUC).For patients with plaque instability,carotid plaque number score and carotid plaque echo score were performed respectively to analyze the correlation between UA/Cr and carotid plaque stability.Finally,in the binary logistic regression model,all independent risk factors are scored according to the OR value to establish an evaluation scale.Results SUA/Cr in the plaque unstable group was signifi-cantly higher than that in the plaque stable group(P＜0.01).The risk of plaque instability increased with the increase of SUA/Cr(OR=3.121,95％CI 2.376～4.099,P＜0.01).The ROC curve shows that the critical value of SUA/Cr is 4.899 and AUC is 0.783.All data were tested by the evaluation scale,and 6 points was the best cut-off value.Conclusions In T2DM patients,SUA/Cr is related to the stability of carotid plaque,and SUA/Cr can be used to indicate the risk of carotid plaque instability.The new scoring standard is a reliable index to predict the stability of carotid plaque.
Type 2 diabetesCarotid plaqueSerum uric acid to creatinine ratio
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