Correlation between glycated hemoglobin in mid-to-late pregnancy and birth weight of offspring in gestational diabetes mellitus patients
Objective To investigate the correlation between the average HbA1c in the second and third trimesters of GDM pregnant women and the birth weight and 6-week weight of their offspring.Methods The data of 556 cases of GDM pregnant women and the 6-week weight of their offspring were collected.The HbA1c of GDM pregnant women was tested every 4-6 weeks until delivery.The average HbA1c in the sec-ond and third trimesters reflected the blood glucose level of the whole pregnancy.Pearson correlation analysis was used to explore the relationship between HbA1c and neonatal birth weight.ROC curve and Logistic re-gression analysis were used to explore the value of HbA1c in predicting the neonatal birth weight of GDM pregnant women.According to different guidelines for HbA1c control targets,the average HbA1c in the second and third trimesters was divided into three subgroups.The differences of birth weight,6-week weight,and adverse pregnancy outcomes of the three subgroups were compared.Results(1)The average HbA1c in the second and third trimester was linearly correlated with neonatal birth weight(P＜0.05).(2)The area under the ROC curve of HbA1c in predicting macrosomia was 0.681,95％CI:0.608～0.753,P＜0.001.When the HbA1c was 5.89％,the sensitivity and specificity of predicting macrosomia were 51.5％and 80.5％,respectively.Two-factor Logistic regression analysis showed that OR=2.307,95％CI:1.215-4.38,P=0.011.(3)The birth weight and adverse pregnancy outcomes of the group C were higher than those of the group A and B(P＜0.05),and the daily weight growth was slower than that of the group A and B(P＜0.05).Conclusion The average HbA1c in the second and third trimester is close-ly related to the birth weight,adverse pregnancy outcomes,and 6-week weight of the offspring of GDM preg-nant women.Its level has predictive value for the occurrence of macrosomia and should be controlled within 6％.
NETL
NSTL
万方数据
