Relationship between leptin,bone metabolic markers and OP in postmenopausal patients with type 2 diabetes mellitus
Objective To investigate the correlation between leptin(LEP),bone metabolism markers,and osteoporosis(OP)in postmenopausal patients with type 2 diabetes mellitus(T2DM).Methods 109 postmenopausal T2DM patients treated in endocrinology department of our hospital from Jan-uary 2020 to December 2021 were retrospectively included and divided into normal group(n=33),reduced group(n=37)and OP group(n=39)according to bone mineral density(BMD)measurement results.The differences of general data and laboratory indexes among the three groups were compared.Multivariate logis-tic regression analysis was used to determine the independent risk factors for OP in postmenopausal T2DM patients.The correlations between LEP,bone metabolism markers and OP were analyzed by Pearson correla-tion.Results The ratio of hyperthyroidism,thyroid stimulating hormone(TSH),glycosylated hemoglobin(HbA1c),LEP and β-CTX of type Ⅰ collagen in OP group were higher than those in normal group and re-duced group.The proportion of insulin treatment,25-hydroxyvitamin D[25(OH)D],osteocalcin(BGP)and N-terminal peptide of total bone type Ⅰ procollagen(TPINP)were lower than those in normal and reduced groups(P＜0.05).Multivariate logistic regression analysis showed that hyperthyroidism,serum LEP andβ-CTX were independent risk factors for OP in postmenopausal T2DM patients(P＜0.05),and insulin ther-apy,25(OH)D,BGP and TPINP were protective factors for OP in postmenopausal T2DM patients(P＜0.05).Pearson correlation analysis showed that serum 25(OH)D,BGP,TPINP were positively corre-lated with OP(P＜0.05).Serum LEP and β-CTX were negatively correlated with OP(P＜0.05).Conclu-sion LEP and bone metabolism markers can reflect the early bone metabolism of postmenopausal T2DM patients and predict the risk of OP.Combined hyperthyroidism,LEP,β-CTX levels increased,insulin treatment,25(OH)D,BGP,TPINP levels decreased,which may be involved in the development of OP in postmenopausal T2DM patients.
diabetes mellitus type 2OsteoporosisLeptinBone metabolic markers
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