Correlation between serum NETs level and left ventricular diastolic function in type 2 diabetic pa-tients
Objective To investigate the relationship between serum NETs levels and left ventricu-lar diastolic function in patients with T2DM(type 2 diabetes mellitus)patients.Methods A total of 107 T2DM patients from October 2022 to May 2023 were selected as the case group,and were divided into T2DM without left ventricular diastolic dysfunction group(group A)and T2DM combined with left ventricu-lar diastolic dysfunction group(group B)according to echocardiography,and 50 patients with age-gender matched normal glucose tolerance were randomly selected as the control group.The serum indexes and echo-cardiogram parameters were detected and compared.Results The levels of NETs in group B were signifi-cantly higher than control group and group A(P＜0.05).In the T2DM group,the level of NETs was nega-tively correlated with left ventricular diastolic function,after adjusting for confounding factors,NETs were independent risk factors affecting E/A values.The optimal tangential value of NETs in the diagnosis of T2DM with left ventricular diastolic dysfunction was NETs=34.11 ng/mL,the diagnostic sensitivity was 0.59,and the specificity was 0.58.Conclusion The level of NETs in T2DM patients is negatively corre-lated with left ventricular diastolic function,which is an independent risk factor for left ventricular diastolic dysfunction in T2DM patients,and has certain diagnostic efficacy for T2DM patients with left ventricular di-astolic dysfunction.
Serum NETs levelType 2 diabetes mellitusLeft ventricular diastolic function
NETL
NSTL
万方数据
