摘要
糖尿病肾脏病(DKD)是糖尿病最常见的并发症之一,也是终末期肾脏病(ESKD)的主要原因.它的发生和发展涉及3个基本组成部分:血流动力学异常、代谢紊乱和炎症反应.临床上定义该病为伴有肾小球滤过率(eGFR)进行性下降的持续性蛋白尿.然而,由于这些改变不是DKD所特有的,因此有必要从发病机制中探讨新的生物标志物,有助于DKD患者的早期诊断、随访、治疗反应和预后评估.
Abstract
Diabetic kidney disease(DKD)is one of the most common complications of diabetes mellitus and the main cause of end-stage renal disease(ESKD).Its development involves three fundamental components:the hemodynamic abnormality,metabolic disorder,and inflammatory response.Clinically,per-sistent albuminuria in association with a progressive decline in glomerular filtration rate(GFR)defines this disease.However,as these alterations are not specific to DKD,there is a need to discuss novel biomarkers arising from its pathogenesis which may aid in the diagnosis,follow-up,therapeutic response,and prognosis of the disease.
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