皮肤与骨质疏松症
Skin and Osteoporosis
杨泓娟 1龚恬 1项守奎1
作者信息
- 1. 苏州大学附属第三医院内分泌代谢科,常州 213003
- 折叠
摘要
骨质疏松症是一种以骨量低下,骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病.皮肤作为人体最大的器官,皮肤结构的相关参数可作为预测骨质疏松症的标志物,例如皮肤厚度、皮肤弹性、体表面积等.研究证明,与皮肤疾病相关的一些炎症因子以及治疗药物影响着骨重塑的平衡;皮肤老化与骨量流失存在一定的相关性,雌激素、晚期糖基化终产物和胱抑素A可能在两者之间发挥着重要作用.本文旨在对皮肤与骨质疏松症的相关性进行综述,进而为骨质疏松症的诊治提供新思路.
Abstract
Osteoporosis is a systemic bone disease characterized by low bone mass and deterioration of bone microstructure,leading to increased bone fragility and susceptibility to fracture.As the largest organ of the body,structurally relevant parameters of the skin can be used as markers to predict osteoporosis,such as skin thickness,skin elasticity,body surface area,etc.It has been demonstrated that some inflammatory factors and therapeutic drugs associated with skin diseases affect the balance of bone remodeling.There is a certain correlation between skin aging and bone mass loss,and estrogen,advanced glycosylation end prod-ucts and cystatin A may play an important role in them.The aim of this paper is to review the correlation be-tween skin and osteoporosis,and thus provide new ideas for the diagnosis and treatment of osteoporosis.
关键词
骨质疏松症/皮肤结构/皮肤疾病/炎性因子/老化Key words
Osteoporosis/Skin Structure/Skin Disease/Inflammatory Factor/Aging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据