Osteoporosis is a systemic bone disease characterized by low bone mass and deterioration of bone microstructure,leading to increased bone fragility and susceptibility to fracture.As the largest organ of the body,structurally relevant parameters of the skin can be used as markers to predict osteoporosis,such as skin thickness,skin elasticity,body surface area,etc.It has been demonstrated that some inflammatory factors and therapeutic drugs associated with skin diseases affect the balance of bone remodeling.There is a certain correlation between skin aging and bone mass loss,and estrogen,advanced glycosylation end prod-ucts and cystatin A may play an important role in them.The aim of this paper is to review the correlation be-tween skin and osteoporosis,and thus provide new ideas for the diagnosis and treatment of osteoporosis.
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