Physical activity level and cardiorespiratory fitness in patients with type 2 diabetes mellitus and meta-bolically associated fatty liver disease and cardiovascular risk
Objective This study explores the effects of physical activity level(PA)and cardiopul-monary fitness(CRF)on the cardiovascular risk score in patients with type 2 diabetes mellitus(T2DM)combined with metabolic-associated fatty liver disease(MAFLD),in order to provide a theoretical basis for improving the cardiovascular prognosis of such patients.Methods 228 patients with T2DM combined with MAFLD were selected and divided into low PA group and moderate/high PA group.The differences in clini-cal and biochemical indicators,energy metabolism indicators,exercise cardiopulmonary indicators,and car-diovascular risk were compared.And through correlation and regression analysis,the effects of PA,CRF,and other factors on the cardiovascular risk of these patients except for traditional cardiovascular risk predic-tors were explored.Results The 10-year cardiovascular risk in the low PA group was significantly higher than that in the moderate/high PA group,while the maximal oxygen uptake(VO2max)and anaerobic threshold(AT)were significantly lower than those in the moderate/high PA group,and the differences were statistically significant(P＜0.05).The 10-year cardiovascular risk was significantly correlated with PA and VO2max.Linear regression analysis showed that PA and the 7-item Generalized Anxiety Disorder Scale(GAD7)were independent correlates of VO2max,while the forced expiratory volume in the first second(FEV1),the maximal minute ventilation(MVV),and VO2max were independent correlates of the 10-year cardiovascular risk.Conclusion The reduction of physical activity and the decline of cardiopulmonary function are important influencing factors for increasing the cardiovascular risk in patients with T2DM com-bined with MAFLD.
Type 2 diabetes mellitusMetabolism-associated steatohepatitisPhysical activityCar-diorespiratory fitnessCardiovascular risk
万方数据
维普
