Interactive effect of SLC16A11 gene polymorphism with pre-pregnancy BMI on the incidence of ges-tational diabetes mellitus
Objective To investigate the relationship between single nucleotide polymorphisms of solute carrier family 16 member 11(SLC16A11)gene and susceptibility to gestational diabetes mellitus(GDM).The interaction between SLC16A11 and pre-pregnancy BMI on GDM was further explored.Meth-ods A total of 1 289 pregnant women who participated in GDM screening in Xiqing District from January 2022 to June 2023 were recruited.SLC16A11 gene rs13342232 was genotyped.Logistic regression was used to analyze the relationship between SLC16A11 gene polymorphism and GDM susceptibility,and inter-action analysis was used to explore the combined effect of different genotypes and pre-pregnancy BMI on the risk of GDM.Results GDM was diagnosed in 260 of 1 289 pregnant women.The polymorphism of rs13342232 locus was significantly associated with co-dominant model(AG vs.AA,OR=1.51,95％CI:1.10-2.06,P=0.010),dominant model(OR=1.48,95％CI:1.09-2.02,P=0.013),overdominant model(OR=1.51,95％CI:1.10-1.85,P=0.011)and additive model(OR=1.40,95％CI:1.05-1.86,P=0.021)were significantly associated with the risk of GDM.Additive interaction was found be-tween rs 13342232 genotype and pre-pregnancy BMI(AP 0.40,95％CI:0.05-0.74).Pregnant women with AG/GG genotype and pre-pregnancy BMI greater than 24 kg/m2 had a higher risk of GDM(OR=2.27,95％CI:1.44-3.54,P＜0.001).Conclusion SLC16A11 gene rs 13342232 polymorphism is significantly associated with the genetic susceptibility to GDM.There is additive interaction between pre-pregnancy BMI and rs13342232 genotype.Pregnant women with AG/GG genotype and pre-pregnancy over-weight have a higher risk of GDM.
Gestational diabetes mellitusSolute carrier family 16 member 11Single nucleotide polymorphismPre-pregnancy body mass indexInteractive effect
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