Association between the triglyceride glucose-body mass index and risk of diabetes mellitus
Objective To investigate the association between triglyceride glucose-body mass index(TyG-BMI)and the risk of diabetes mellitus,and to assess the predictive ability of TyG-BMI for the new onset of diabetes mellitus.Methods A total of 7 408 participants with normal baseline blood glucose levels were selected from the China Health and Retirement Longitudinal Study(CHARLS)and were followed up for 7 years.The Cox proportional hazard regression model was used to evaluate the association between TyG-BMI and diabetes in the whole population and subgroups.Receiver operating characteristic(ROC)curve,calibration curve,Decision Curve Analysis curve,and Net Reclassification Improvement index were used to evaluate the predictive ability of TyG-BMI.Results A total of 949 newly diagnosed diabetic cases were identified during follow-up,with an incidence rate of 12.81％.The incidences of diabetes in the four subgroups divided by the quartiles of baseline TyG-BMI were 8.32％,9.48％,12.22％,and 21.22％,re-spectively(all Pfortrend＜0.001).For each standard deviation increase in TyG-BMI,the risk of diabetes in-creased by 95.6％(95％CI:50.6％-154.1％).People with a high TyG-BMI under 65 years of age were more likely to develop diabetes(Pinteaction=0.046).The cutoff value for TyG-BMI in predicting diabetes was 198.90.Adding TyG-BMI to the clinical prediction model improved the predictive power of the model.Conclusions TyG-BMI is an independent predictor of new-onset diabetes,especially among people under 65 years of age.
Triglyceride glucose body mass indexDiabetes mellitusClinical prediction modelChina health and retirement longitudinal study
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