Correlation analysis of the interaction between paraoxonase 1 and thyroid antibodies on the risk of abortion in patients with normal thyroid function undergoing assisted reproduction
Objective To investigate the influencing factors of abortion in patients with intact thy-roid function underlying assisted reproductive technology and explore whether the interaction between paraox-onase 1(PON1)and thyroid antibodies correlated with the onset of miscarriage.Methods A total of 165 patients preparing for assisted reproduction were retrospectively selected,according to whether the patients had miscarriages,patients were divided into two groups,with 27 cases in the miscarriage group and 138 ca-ses in group without miscarriage.The differences in medical history and laboratory tests between the two groups were compared.The interaction between PON1 and thyroid antibodies on abortion was analyzed by binary logistic regression.Results After adjusting for age,body mass index,infertility years,thyroid stim-ulating hormone,free triiodothyronine,free thyroxine,luteinizing hormone,follicle stimulating hormone,testosterone,estradiol,prolactin,anti-mullerian hormone,number of retrieved eggs,number of fertilized em-bryos,and number of transferred embryos,both PON1 and thyroid antibodies had significant associations with miscarriage(β=1.669,95％CI:1.044-2.668,P=0.032;β=3.834,95％CI:1.085-13.546,P=0.037).A significant interaction was observed between PON1 and thyroid antibodies in relation to abortion(Pinteraction＜0.046).The subgroup analysis of PON1 and thyroid antibodies showed that the high level PON1 and thyroid antibody positive group had a 15.375 times higher risk of miscarriage compared to the low level PON1 and thyroid antibody negative group.Conclusion High level PON1 and thyroid antibodies have an in-teraction on the occurrence of abortion in women underlying assisted reproductive technology.The presence of thyroid antibodies and elevated levels of PON1 may be related to the elevated risk of miscarriage.
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