Retrospective cohort study on blood glucose level and non-alcoholic fatty liver disease
Objective To investigate the relationship between blood glucose fluctuations and non-alcoholic fatty liver disease(NAFLD).Methods The scope of this study was 4 360 subjects who under-went physical examinations at the hospital between December 2010 and December 2014.Based on the fasting blood glucose levels of the subjects in 2010 and 2014,they were divided into four groups:normal-normal groupa,normal-abnormal groupa,abnormal-normal groupa,and abnormal-abnormal groupa.Similarly,based on the subjects'OGTT 2-hour glucose levels in 2010 and 2014,they were divided into four groups:normal-normal groupb,normal-abnormal groupb,abnormal-normal groupb,and abnormal-abnormal groupb.The risk of developing NAFLD in 2014 was assessed.Results Among all participants,1 505 were newly diagnosed with NAFLD in 2014.According to the classification of fasting blood glucose levels,31.0％,40.9％,32.3％,and 44.5％of participants were newly diagnosed with NAFLD in the normal-normal groupa,nor-mal-abnormal groupa,abnormal-normal groupa,and abnormal-abnormal groupa,respectively.According to the blood glucose levels after 2 hours of glucose load,28.3％,30.8％,40.0％,and 45.2％of partici-pants were newly diagnosed with NAFLD in the normal-normal groupb,normal-abnormal groupb,abnor-mal-normal groupb,and abnormal-abnormal groupb,respectively.There was a significant relationship be-tween the conversion of fasting blood glucose from normal to abnormal and NAFLD(P＜0.000 1),while there was no statistically significant difference in the relationship between the conversion of blood glucose from normal to abnormal with NAFLD after 2 hours of glucose loading(P=0.255).After adjusting for mul-tiple confounding factors,it was found that compared to the normal-normal groupa,the odds ratio(OR)(95％confidence interval,95％CI)of the normal-abnormal groupa was 1.484(1.190-1.850),and the OR and 95％CI of the abnormal-abnormal groupa were 1.600(1.335-1.918).Conclusion The correla-tion between elevated blood glucose and NAFLD through a large amount of data is explored,and finds that fasting hyperglycemia is associated with the risk of developing NAFLD is found.
Nonalcoholic fatty liver diseaseBlood glucose fluctuationsRisk of disease
万方数据
