Gestational diabetes mellitus(GDM)is a common complication during pregnancy,and significantly impacts the health of the mother and fetus.It has been shown that the moderate invasion of pla-cental trophoblast cells plays a key role in GDM.However,the specific mechanisms of this process are not yet fully understood.Pyruvate kinase M2(PKM2),one of the three main rate-limiting enzymes in glycoly-sis,plays a crucial role in cellular energy supply,invasiveness,metastasis,and cell proliferation.Studies have explored the invasiveness of placental trophoblast cells in patients with GDM,as well as the structure,regulatory functions,and post-translational modifications of PKM2.However,current research on the spe-cific role and mechanism of PKM2 in the placenta of GDM patients is still lacking.Therefore,an in-depth study of the pathogenesis of GDM is of great significance for the development of more effective treatment and prevention strategies.
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