Metabolic-associated fatty liver disease(MAFLD)is a multi-system metabolic disorder caused by multiple factors influencing each other,and is closely related to the development of hypertension,obesity,diabetes mellitus,coronary atherosclerotic heart disease,and chronic kidney disease.There is in-creasing evidence that MAFLD can lead to cognitive impairment,which seriously disturbs patients'daily lives.MAFLD represents a modifiable risk factor for cognitive impairment.The implementation of early and active prevention strategies can help to slow down the process of cognitive impairment.This review summari-zes the research progress on cognitive impairment caused by MAFLD in terms of hepatic insulin resistance,neuroinflammation,disruption of the gut-hepatic-brain axis,elevated blood ammonia,and cerebral vascular lesions in recent years,which also provides novel insights for therapeutic approaches to the secondary cogni-tive impairment associated with MAFLD.
万方数据